"LGALS3" Related Products

Expand
Expand
Expand

Recombinant Human LGALS3 protein

Cat.No.: LGALS3-4952H
Product Overview: Recombinant Human LGALS3, a single, non-glycosylated, polypeptide chain was expressed in E. coli.
Description: Galectin-3 mediates with the alpha-3, beta-1 integrin the stimulation by cspg4 of endothelial cells migration. Galectin-3 plays an necessary part during the acquisition of vasculogenic mimicry and angiogenic properties associated with melanoma progression. LGALS3 overexpression is highly expressed in early stages of papillary carcinoma, and its expression intensity declines during tumor progression. Serum levels of LGALS3 are high in patients with thyroid malignancy but there is considerable overlap in serum LGALS3 concentrations between those with benign and malignant nodular thyroid disease. LGLAS3 takes part as an immune regulator to inhibit T-cell immune responses and promote tumor growth, as a result providing a new mechanism for tumor immune tolerance.
Source: E. coli
Species: Human
Form: The Galectin-3 protein was lyophilized from a 0.2µm filtered concentrated solution in PBS, pH 7.4 and 3mM DTT.
Bio-activity: The ED50 as determined by its ability to agglutinate human red blood cells is less than 10 µg/ml.
Molecular Mass: 26kDa
Protein length: 249 amino acids
AA Sequence: ADNFSLHDAL SGSGNPNPQG WPGAWGNQPA GAGGYPGASY PGAYPGQAPP GAYPGQAPPG AYPGAPGAYP GAPAPGVYPG PPSGPGAYPS SGQPSATGAY PATGPYGAPA GPLIVPYNLP LPGGVVPRML ITILGTVKPN ANRIALDFQR GNDVAFHFNP RFNENNRRVI VCNTKLDNNW GREERQSVFP FESGKPFKIQ VLVEPDHFKV AVNDAHLLQY NHRVKKLNEI SKLGISGDID LTSASYTMI.
Purity: Greater than 97.0% as determined by analysis by SDS-PAGE and HPLC.
Stability: Lyophilized Galectin-3 Recombinant although stable at room temperature for 3 weeks, should be stored desiccated below -18 centigrade. Upon reconstitution Galectin-3 should be stored at 4 centigrade between 2-7 days and for future use below -18 centigrade.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Reconstitution: It is recommended to reconstitute the lyophilized LGALS3 in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Gene Name: LGALS3 lectin, galactoside-binding, soluble, 3 [ Homo sapiens ]
Official Symbol: LGALS3
Synonyms: LGALS3; lectin, galactoside-binding, soluble, 3; LGALS2; galectin-3; galectin 3; GALIG; MAC 2; lectin L-29; 35 kDa lectin; MAC-2 antigen; IgE-binding protein; laminin-binding protein; galactose-specific lectin 3; carbohydrate-binding protein 35; L31; GAL3; MAC2; CBP35; GALBP;
Gene ID: 3958
mRNA Refseq: NM_001177388
Protein Refseq: NP_001170859
MIM: 153619
UniProt ID: P17931
Chromosome Location: 14q22.3
Pathway: Advanced glycosylation endproduct receptor signaling, organism-specific biosystem; Hedgehog signaling events mediated by Gli proteins, organism-specific biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem;
Function: IgE binding; protein binding; sugar binding;

Online Inquiry

Note: There will be extra charge for optional service!

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional requirements on this protein    +Expand

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.