Recombinant Human CD4 Molecule, His-tagged (125-202aa)

Cat. No.: CD4-101H
Product Overview: Recombinant Human CD-4 is expressed in E. coli encoding 125-202 amino acids, having a total molecular weight of 15kDa and fused to an amino terminal hexahistidine tag.
Description: CD4, a single chain transmembrane glycoprotein, is found on a T cell subset (helper/inducer) representing 45% of peripheral blood lymphocytes. It is also present on 80% of thymocytes and at a lower level on monocytes. It is involved in recognition of antigen presented along with MHC class II by APCs. It serves as receptor for HIV. Antibody to CD4 recognizes T-helper cells required for recognition of class II antigens. It reacts with ~60% of peripheral blood E rosette-positive (E+) cells while showing negligible reactivity with E-cells, monocytes, granulocytes, EBV-transformed B cell lines, and mouse splenocytes.
Source: Escherichia Coli.
Physical Appearance: Sterile lyophilized powder.
Purity: Greater than 90% determined by SDS-PAGE.
Formulation: Each mg contains 1X PBS.
Solubility: It is recommended to reconstitute the lyophilized CD-4 (125-202) in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Application: • Protein Assay • Antibody Production • Western Blotting
Storage: Store vial at -20°Cto -80°C. When stored at the recommended temperature, this protein is stable for 12months. Please avoid freeze-thaw cycles.
Gene Name: CD4 CD4 molecule [ Homo sapiens ]
Synonyms: CD4; CD4 molecule; CD4mut; T-cell surface glycoprotein CD4; CD4 antigen (p55); T-cell surface antigen T4/Leu-3; CD_antigen; CD4 antigen; CD4 receptor
Gene ID: 920
mRNA Refseq: NM_000616
Protein Refseq: NP_000607
MIM: 186940
UniProt ID: P01730
Chromosome Location: 12pter-p12
Pathway: Antigen processing and presentation; Cell adhesion molecules (CAMs); Hematopoietic cell lineage; Primary immunodeficiency; T cell receptor signaling pathway; HIV Infection; Signaling in Immune system
Function: MHC class II protein binding; coreceptor activity; extracellular matrix structural constituent; protein homodimerization activity; protein kinase binding; transmembrane receptor activity; zinc ion binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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