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Recombinant Human CUL1, GST-tagged

Cat.No. : CUL1-11701H
Product Overview : Recombinant Human CUL1 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
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Source : E.coli
Species : Human
Tag : GST
Protein length : C-term-352a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : CUL1 cullin 1 [ Homo sapiens ]
Official Symbol : CUL1
Synonyms : CUL1; cullin 1; cullin-1; CUL-1; MGC149834; MGC149835;
Gene ID : 8454
mRNA Refseq : NM_003592
Protein Refseq : NP_003583
MIM : 603134
UniProt ID : Q13616
Chromosome Location : 7q36.1
Pathway : APC/C-mediated degradation of cell cycle proteins, organism-specific biosystem; Activation of NF-kappaB in B Cells, organism-specific biosystem; Adaptive Immune System, organism-specific biosystem; Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem; Canonical Wnt signaling pathway, organism-specific biosystem; Cell Cycle, organism-specific biosystem;
Function : protein binding; ubiquitin protein ligase binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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What techniques are used to study the expression and function of CUL1 protein in clinical research? 02/09/2023

Techniques such as immunohistochemistry, Western blotting, and gene expression analysis are commonly used to study CUL1 protein expression and function in clinical research.

Is CUL1 protein involved in any other diseases besides cancer? 11/11/2022

Yes, CUL1 protein has been implicated in various diseases, including neurodegenerative disorders and cardiovascular diseases, due to its role in protein degradation and cellular regulation.

Can CUL1 protein be used as a biomarker for cancer diagnosis? 05/07/2020

While CUL1 protein levels are altered in certain cancers, it is not commonly used as a standalone biomarker. However, it may be part of a panel of markers used for cancer diagnosis.

Are there any genetic disorders associated with CUL1 protein mutations? 08/21/2017

Yes, mutations in the CUL1 gene have been linked to a rare genetic disorder called Cullin-Ring Ligase 1 Syndrome, which is characterized by developmental delays and intellectual disabilities.

How does the dysregulation of CUL1 protein impact cell cycle progression? 02/18/2017

Dysregulation of CUL1 protein can lead to the abnormal degradation of cell cycle regulators, resulting in uncontrolled cell division and potentially contributing to tumorigenesis.

Customer Reviews (3)

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06/16/2021

    I highly recommend the CUL1 protein for a variety of research applications.

    05/08/2016

      It demonstrates excellent performance in ELISA, consistently delivering accurate and reliable results.

      04/05/2016

        the CUL1 protein has proven to be an invaluable tool in protein electron microscopy structure analysis.

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