"IL4" Related Products

Recombinant Porcine IL4

Cat.No.: IL4-9291P
Product Overview: Recombinant Porcine IL4 was expressed in CHO Cells.
Description: Interleukin-4 (IL-4) is a pleiotropic cytokine regulates diverse T and B cell responses including cell proliferation, survival, and gene expression. It has important effects on the growth and differentiation of different immunologically competent cells. Interleukin-4 is produced by mast cells, T cells, and bone marrow stromal cells. IL-4 regulates the differentiation of native CD4+ T cells (Th0 cells) into helper Th2 cells, and regulates the immunoglobulin class switching to the IgG1 and IgE isotypes. IL-4 has numerous important biological functions including stimulating B-cells activation, T-cell proliferation and CD4+ T-cells differentiation to Th2 cells. It is a key regulator in hormone control and adaptive immunity. IL-4 also plays a major role in inflammation response and wound repair via activation of macrophage into M2 cells. IL-4 is stabilized by three disulphide bonds forming a compact globular protein structure. Four alpha-helix bundle with left-handed twist is dominated half of the protein structure with 2 overhand connections and fall into a 2-stranded anti-parallel beta sheet.
Source: CHO Cells
Species: Porcine
Form: Lyophilized after extensive dialysis against PBS.
Bio-activity: ED50< 0.25 ng/ml, measured in a cell proliferation assay using tf-1 human erythroleukemic cells, corresponding to a specific activity of>4 x 106 units/mg
Molecular Mass: 15kDa, observed by reducing SDS-PAGE
AA Sequence: His25-Cys133, expressed with an N-terminal Met.
Endotoxin: <0.2 eu/μg, determined by lal>
Purity: >95% as analyzed by SDS-PAGE and HPLC.
Storage: Lyophilized recombinant protein remains stable up to 6 months at -80°C from date of receipt. Upon reconstitution, rpIL-4 should be stable up to 1 week at 4°C or up to 2 months at -20°C.
Reconstitution: Reconstituted in ddH2O or PBS at 100 μg/ml.
Gene Name: IL4 interleukin 4 [ Sus scrofa (pig) ]
Official Symbol: IL4
Synonyms: IL4; interleukin 4; interleukin-4; IGG1 induction factor; B-cell growth factor 1; B-cell stimulatory factor 1; lymphocyte stimulatory factor 1; B-cell IgG differentiation factor; Il-4; BSF-1;
Gene ID: 397225
mRNA Refseq: NM_214123
Protein Refseq: NP_999288
UniProt ID: Q04745
Chromosome Location: 2; 2
Pathway: Allograft rejection, organism-specific biosystem; Allograft rejection, conserved biosystem; Asthma, organism-specific biosystem; Asthma, conserved biosystem; Autoimmune thyroid disease, organism-specific biosystem; Autoimmune thyroid disease, conserved bi

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