"IL36A" Related Products

Recombinant Mouse Il1f6

Cat.No.: Il1f6-550M
Product Overview: Recombinant Mouse Il1f6 produced in E. coli is approximately 18.0 kDa, a single non-glycosylated polypeptide chain containing 160 amino acids.
Description: Interleukin-36 (IL-36) is a pro-inflammatory cytokine which plays an important role in the pathophysiology of several diseases. IL-36α, IL-36β, and IL-36γ (formerly IL-1F6, IL-1F8, and IL-1F9) are IL-1 family members that signal through the IL-1 receptor family members IL-1Rrp2 (IL-1RL2) and IL-1RAcP. IL-36α is mainly found in skin and lymphoid tissues, but also in fetal brain, trachea, stomach and intestine. It is expressed by monocytes, B and T cells. Notably, IL-36 alpha is the only novel IL-1 family member expressed on T-cells. Recombinant murine interleukin-36 alpha contains 160 amino acids residues which is a single non-glycosylated polypeptide. Specifically, mouse IL-36α shares 83 % a.a. sequence identity with rat IL-36α, 54-60 % with human, rabbit, equine and bovine IL-36α.
Source: E. coli
Species: Mouse
Form: Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4, 5 % trehalose.
Bio-activity: Fully biologically active when compared to standard. The ED 50 determined by its ability to induce IL-8 secretion by human preadipocytes is less than 10 ng/ml, corresponding to a specific activity of >1 × 10^5 IU/mg.
Molecular Mass: 18 kDa
Endotoxin: Less than 1 EU/μg of rMuIL-36α, 160a.a. as determined by LAL method.
Purity: >95% by SDS-PAGE and HPLC analyses.
Usage: This material is for research, laboratory or further evaluation purposes. NOT FOR HUMAN USE.
Storage: This lyophilized preparation is stable at 2-8 centigrade, but should be kept at -20 centigrade for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 centigrade. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 centigrade to -70 centigrade. Avoid repeated freeze/thaw cycles.
Reconstitution: We recommend that this vial be briefy centrifuged prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. Stock solutions should be apportioned into working aliquots and stored at ≤ -20 centigrade. Further dilutions should be made in appropriate buffered solutions.
Gene Name: Il1f6 interleukin 1 family, member 6 [ Mus musculus ]
Official Symbol: Il1f6
Synonyms: IL1F6; interleukin 1 family, member 6; interleukin-36 alpha; IL-1F6; Fil1epsilon; FIL1 epsilon; IL-1 epsilon; interleukin-1 epsilon; interleukin-1 homolog 1; interleukin-1 family member 6; interleukin 1 family, member 9; interleukin 1 family, member 6 (epsilon); Fil1; Il1f9; Il36a; IL-1H1; IL1RP2; MGC151479; MGC151481;
Gene ID: 54448
mRNA Refseq: NM_019450
Protein Refseq: NP_062323
Function: cytokine activity; interleukin-1 receptor antagonist activity; interleukin-1 receptor binding;

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