Native Human BGLAP protein

• Cat.No.: BGLAP-60H
• Product Overview: Native Human BGLAP was purified from Human blood/plasma.

Specification

• Description: This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product.
• Source: Human blood/plasma
• Species: Human
• Form: 20 mM Tris, 150 mM NaCl, pH 7.4
• Molecular Mass: 5,800
• Purity: >95% by SDS-PAGE
• Characteristic: Single chain, one intrachain disulfide bond, Cys 23-29. Three gla residues, 17, 21, 24. Isoelectric Point: 4.0-4.5.
• Notes: Although the starting material was tested prior to initiation of the manufacturing process, and was found negative or nonreactive for anti-HIV-1/2, HIV-1 antigen(s), HBsAg, STS, antiHCV, anti-HBcore and anti-HTLV I & II, extreme caution should be used when handling this material as there is a margin of error in all tests.
• Storage: Store product at or below –80 centigrade.
• Concentration: 0.68 mg/ml

Gene Information

• Gene Name: BGLAP bone gamma-carboxyglutamate (gla) protein [ Homo sapiens ]
• Official Symbol: BGLAP
• Synonyms: BGLAP; bone gamma-carboxyglutamate (gla) protein; osteocalcin; bone Gla protein; gamma-carboxyglutamic acid-containing protein; bone gamma-carboxyglutamate (gla) protein (osteocalcin); OC; BGP
• Gene ID: 632
• mRNA Refseq: NM_199173
• Protein Refseq: NP_954642
• MIM: 112260
• UniProt ID: P02818
• Chromosome Location: 1q25-q31
• Pathway: Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; DNA Replication, organism-specific biosystem; FGF signaling pathway, organism-specific biosystem; Glucocorticoid receptor regulatory network, organism-specific biosystem; M Phase, organism-specific biosystem; Mitotic M-M/G1 phases, organism-specific biosystem
• Function: calcium ion binding; hydroxyapatite binding; structural constituent of bone; structural molecule activity