Native Human BGLAP protein
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Cat.No. : | BGLAP-60H |
Product Overview : | Native Human BGLAP was purified from Human blood/plasma. |
Description : | This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. |
Source : | Human blood/plasma |
Species : | Human |
Form : | 20 mM Tris, 150 mM NaCl, pH 7.4 |
Molecular Mass : | 5,800 |
Purity : | >95% by SDS-PAGE |
Characteristic : | Single chain, one intrachain disulfide bond, Cys 23-29. Three gla residues, 17, 21, 24. Isoelectric Point: 4.0-4.5. |
Notes : | Although the starting material was tested prior to initiation of the manufacturing process, and was found negative or nonreactive for anti-HIV-1/2, HIV-1 antigen(s), HBsAg, STS, antiHCV, anti-HBcore and anti-HTLV I & II, extreme caution should be used when handling this material as there is a margin of error in all tests. |
Storage : | Store product at or below –80 centigrade. |
Concentration : | 0.68 mg/ml |
Gene Name : | BGLAP bone gamma-carboxyglutamate (gla) protein [ Homo sapiens ] |
Official Symbol : | BGLAP |
Synonyms : | BGLAP; bone gamma-carboxyglutamate (gla) protein; osteocalcin; bone Gla protein; gamma-carboxyglutamic acid-containing protein; bone gamma-carboxyglutamate (gla) protein (osteocalcin); OC; BGP; |
Gene ID : | 632 |
mRNA Refseq : | NM_199173 |
Protein Refseq : | NP_954642 |
MIM : | 112260 |
UniProt ID : | P02818 |
Chromosome Location : | 1q25-q31 |
Pathway : | Cell Cycle, organism-specific biosystem; Cell Cycle, Mitotic, organism-specific biosystem; DNA Replication, organism-specific biosystem; FGF signaling pathway, organism-specific biosystem; Glucocorticoid receptor regulatory network, organism-specific biosystem; M Phase, organism-specific biosystem; Mitotic M-M/G1 phases, organism-specific biosystem; |
Function : | calcium ion binding; hydroxyapatite binding; structural constituent of bone; structural molecule activity; |
◆ Recombinant Protein
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Bglap-1143R | Recombinant Rat Bglap Protein, GST-tagged | +Inquiry |
BGLAP-010H | Recombinant Human BGLAP Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
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BGLAP-706R | Recombinant Rabbit BGLAP Protein, His/GST-tagged | +Inquiry |
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◆ Native Protein
BGLAP-8519B | Native Bovine BGLAP | +Inquiry |
BGLAP-57H | Native Human Osteocalcin | +Inquiry |
BGLAP-59B | Native Bovine Osteocalcin | +Inquiry |
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◆ Lysates
BGLAP-8460HCL | Recombinant Human BGLAP 293 Cell Lysate | +Inquiry |
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