Recombinant Human Cathepsin D CTSD-90H

Recombinant Human Cathepsin D

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Recombinant Human Cathepsin D

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Cat. No. : CTSD-90H
Product Overview : Recombinant full length human Catheprsin D protein expressed inE.coli,48kDa.
Description : Cathepsin D is synthesized as a 54kDa precursor, which is proteolytically processed to an intermediate 48kDa single chain, which matures into more stable 34kDa and 14kDa two chain form. It is an estrogen-regulated lysosomal protease that has been suggested to facilitate cancer cell migration and invasion by digesting the basement membrane, extracellular matrix, and xonnective tissue. Because of its mitogenic and proteolytic activities, it has been implicated as a prognostic marker in many tumor types. Cathepsin D is expressed in epithelial cells as well as in macrophages.
Source : E.coli
Presentation : 5µg/50µl purified human Cathepsin D protein at 0.1mg/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.
Applications : •ELISA •Inhibition Assays •Western Blotting
Characterization : On SDS-PAGE commassie blue stained gel, the purified recombinant protein shows a band at 48kDa.
Activity : Not known.
Storage : Store vial at -20°Cto -80°C. When stored at the recommended temperature, this protein is stable for 12 months.
PDB rendering based on 1lya. :

Gene Name : CTSD cathepsin D [ Homo sapiens ]
Synonyms : CTSD; cathepsin D; CPSD; CLN10; MGC2311; lysosomal aspartyl protease; lysosomal aspartyl peptidase; ceroid-lipofuscinosis, neuronal 10; EC 3.4.23.5; cathepsin D (lysosomal aspartyl protease);Cathepsin D light chain; Cathepsin D heavy chain
Gene ID : 1509
mRNA Refseq : NM_001909
Protein Refseq : NP_001900
MIM : 116840
UniProt ID : P07339
Chromosome Location : 11p15.5
Pathway : Lysosome
Function : aspartic-type endopeptidase activity; peptidase activity

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