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Recombinant Human SRC, SH3 Domain, GST-tagged

Cat.No. : SRC-192H
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Cat. No. : SRC-192H
Description : N-terminal GST tagged Src SH3 domain. Src SH3 domain is the SH3 domain of Src tyrosine kinase. SH3 domains are known to bind proline rich peptides. The Src SH3 domain has been expressed as a fusion protein with GST allowing expression in E. coli and purification by affinity chromatography. The native GST-Src-SH3 is the ideal tool for in vitro/in vivo investigations of the behaviour of cellular prions. It may be used for protein-protein interaction studies as well as forin vitro/in vivoconversion studies. The GST-Tag facilitates the protein's application in typical GST pull-down assays.
Source : E. coli.
Form : Lyophilized.
Purity : ≥90% by SDS-PAGE.
Usage : For in vitro use only.
Storage : Quality guaranteed for 12 months store at -80°C. Avoid freeze / thaw cycles.
Gene Name : SRC v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [ Homo sapiens ]
Synonyms : SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); ASV; SRC1; c-SRC; p60-Src; proto-oncogene tyrosine-protein kinase SRC; OTTHUMP00000174476; OTTHUMP00000174477; tyrosine kinase pp60c-src; tyrosine-protein kinase SRC-1; protooncogene SRC, Rous sarcoma; EC 2.7.10.2; pp60c-src; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogenehomolog
Gene ID : 6714
mRNA Refseq : NM_005417
Protein Refseq : NP_005408
MIM : 190090
UniProt ID : P12931
Chromosome Location : 20q12-q13
Pathway : Adherens junction; Endocytosis; Epithelial cell signaling in Helicobacter pylori infection; ErbB signaling pathway; Focal adhesion; Gap junction; GnRH signaling pathway; Tight junction; VEGF signaling pathway
Function : ATP binding; SH2 domain binding; SH3/SH2 adaptor activity; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; transferase activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How do alterations in SRC expression or activity affect the development of drug resistance in tumors? 10/23/2022

Changes in SRC expression or kinase activity can lead to drug resistance in cancer treatment.

How does SRC (proto-oncogene tyrosine-protein kinase Src) regulate cell proliferation and survival? 07/08/2021

SRC regulates cell proliferation and survival through its kinase activity, influencing various signaling pathways.

How does SRC contribute to the regulation of bone remodeling and osteoclast activity? 06/26/2020

SRC is involved in bone remodeling, regulating osteoclast activity and bone resorption.

What role does SRC play in cancer development and progression, particularly in metastasis? 03/16/2020

SRC plays a crucial role in cancer progression, particularly in enhancing metastatic potential of tumor cells.

How does SRC influence cellular signaling pathways, such as the Ras/MAPK and PI3K/Akt pathways? 12/06/2019

SRC influences key cellular signaling pathways like Ras/MAPK and PI3K/Akt, affecting cell growth and survival.

What are the mechanisms by which SRC modulates cellular adhesion and migration? 03/27/2019

SRC modulates cellular adhesion and migration, playing a role in tissue repair and cancer metastasis.

What is the impact of SRC inhibition on targeted cancer therapies? 01/02/2018

SRC inhibition is a target in cancer therapy, potentially reducing tumor growth and metastasis.

Customer Reviews (3)

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Reviews
01/01/2022

    Top-notch protein purification service, essential for our research.

    08/29/2019

      Reliable mass spectrometry analysis, pivotal for our proteomics work.

      03/02/2019

        Swift and reliable protein sequencing, indispensable for our research success.

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