"FYN" Related Products

Expand
Expand

Recombinant Human FYN, GST-tagged, Active

Cat. No.: FYN-322H
Product Overview: Recombinant human Full-length FYN A was expressed by baculovirus inSf9 cellsusing an N-terminal GST tag. MW=85kDa.
Description: Fyn A (Fyn isoform A) is a member of the SRC tyrosine kinase oncogene family showing high homology to YES1, FGR and SRC. Fyn has been shown to phosphorylate Dab1, an intracellular adaptor protein that interacts with amyloid precursor protein (APP) and apoE receptor 2 (apoEr2). The interaction of Fyn and Dab1 regulates the phosphorylation, trafficking, and processing of APP and apoEr2. Fyn expression has been shown to be significantly increased in Chronic Myelogenous Leukemia (CML). Knockdown of Fyn with shRNA slows leukemia cell growth, inhibits clonogenicity, and leads to increased sensitivity to imatinib.
Source: Sf9 insect cells using baculovirus.
Sequence: Full-length.
Applications: Kinase Assay, Western Blot.
Storage And Stability: Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Gene Name: FYN FYN oncogene related to SRC, FGR, YES [ Homo sapiens ]
Synonyms: FYN oncogene related to SRC, FGR, YES; SLK; SYN; MGC45350; FYN; proto-oncogene tyrosine-protein kinase fyn; src-like kinase; Protooncogene Syn; OTTHUMP00000017917; c-syn protooncogene; src/yes-related novel; tyrosine kinase p59fyn(T); p59-Fyn; protein-tyrosine kinase fyn ; OKT3-induced calcium influx regulator; EC 2.7.10.2; OTTHUMP00000017915; OTTHUMP00000017914; src-like kinase
Gene ID: 2534
mRNA Refseq: NM_002037
Protein Refseq: NP_002028
UniProt ID: P06241
Chromosome Location: 6q21
MIM: 137025
Pathway: Adherens junction; Axon guidance; Fc epsilon RI signaling pathway; Focal adhesion; Natural killer cell mediated cytotoxicity; Pathogenic Escherichia coli infection; Prion diseases; T cell receptor signaling pathway
Function: non-membrane spanning protein tyrosine kinase activity; ATP binding; glycoprotein binding; identical protein binding; manganese ion binding; metal ion binding; nucleotide binding; transferase activity; tubulin binding

Online Inquiry

Note: There will be extra charge for optional service!

Please input "biomart" as verification code. Please review Creative BioMart's privacy policy for more information

Optional requirements on this protein    +Expand

Price Inquiry

Welcome! For price inquiries, please feel free to contact us through the form below. We will get back to you as soon as possible.