Recombinant Murine Interleukin 12a
Cat.No. : | Il12a-209M |
Product Overview : | Recombinant murine IL-12-p40 is a 40.0 kDa protein containing 313 amino acid residues. It is expressed inCHO cells. MW=40kDa. |
- Specification
- Gene Information
- Related Products
Cat. No. : | Il12a-209M |
Description : | Interleukin-12 is a disulfide-linked heterodimeric protein (p70), composed of two subunits, p35 and p40, which are encoded by two different genes. Accumulating data indicate that p40 secretion precedes that of IL-12 expression. In addition, to its ability to covalently bind to p35 to form IL-12, p40 can bind to p19 to form IL-23. |
Source : | CHO cells. |
Purity : | Greater than 95% (determined by SDS-PAGE and HPLC analysis). |
Specific Activity : | NA. |
Endotoxin Level : | < 0.1 ng per µg of rMu IL-12-p40 (1EU/µg). |
Biological Activity : | NA. |
Formulation : | Lyophilized from a sterile-filtered solution with no additives. |
Reconstitution : | Please Note: Always centrifuge product before opening vial. The lyophilized protein should be reconstituted with distilled, sterile water to a concentration of 0.1-1.0 mg/ml. For further dilution, carrier protein (0.1% BSA or HSA) should be added to avoid loss of bioactivity. |
Storage : | The lyophilized protein, though stable at room temperature for up to 3 weeks, is best stored desiccated at -20°C. Reconstituted protein should be used immediately or stored long-term in undiluted working aliquots at -20°C. For long-term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze-thaw cycles. |
Gene Name : | Il12a interleukin 12a [ Mus musculus ] |
Synonyms : | Il12a; interleukin 12a; p35; Ll12a; Il-12a; IL-12p35; MGC151228; MGC151232; interleukin 12a p35 subunit; interleukin 12a |
Gene ID : | 16159 |
mRNA Refseq : | NM_001159424 |
Protein Refseq : | NP_001152896 |
UniProt ID : | P43431 |
Chromosome Location : | 3 E1; 3 37.0 cM |
Pathway : | Allograft rejection; Cytokine-cytokine receptor interaction; RIG-I-like receptor signaling pathway; Jak-STAT signaling pathway; Toll-like receptor signaling pathway; Type I diabetes mellitus |
Function : | cytokine activity; growth factor activity; interleukin-12 beta subunit binding; interleukin-12 receptor binding |
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Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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- Reviews
Q&As (10)
Ask a questionMass spectrometry identifies IL12A's post-translational modifications and their roles.
Knockout models validate IL12A's roles in immune response modulation.
Protein footprinting assays reveal IL12A's binding interfaces with receptors.
ELISA and stability assays quantify IL12A secretion and stability in culture.
SPR characterizes IL12A's interactions with antibodies and inhibitors.
Cellular assays gauge IL12A's cytokine induction in immune cells.
Isothermal titration calorimetry measures IL12A's binding affinity with receptors.
Structural biology techniques analyze IL12A genetic variant impacts.
Site-directed mutagenesis probes IL12A's functional domains and interactions.
Bioluminescence imaging tracks IL12A expression dynamics in vivo.
Customer Reviews (3)
Write a reviewSuitable for co-immunoprecipitation.
Consistent in bioactivity.
Good for receptor binding studies.
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