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Recombinant Human Transforming Growth Factor, Beta Receptor III

Cat.No. : TGFBR3-1685H
Product Overview : Recombinant Human TGFBR3 encoding the amino terminal 781 amino acid residue extracellular domain of human TGF-β receptor type III was inserted into a suitable mammalian expression vector and expressed in a mouse myeloma cell line,NSO.
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Cat. No. : TGFBR3-1685H
Description : Transforming growth factor-beta (TGF-beta) signals through three highly conserved cell surface receptors, the type III TGF-beta receptor (T beta RIII), the type II TGF-beta receptor (T beta RII), and the type I TGF-beta receptor (T beta RI) to regulate diverse cellular processes including cell proliferation, differentiation, migration, and apoptosis. T beta RIII is a heparan sulfate proteoglycan with a short cytoplasmic tail that functions as a TGF-beta superfamily co-receptor, contributing to TGF-beta signaling. T-beta-RIII might provide a mechanism for the distinct effects of TGF-beta at the different stages of breast cancer.
Molecular Weight : The predicted molecular weight of Recombinant Human TGF-β soluble Receptor III is Mr 84 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 100 kDa.
Source : Mammalian cells
State Of Matter : Lyophilized.
Purity : >90% by SDS Page and analyzed by silver stain.
Endotoxin : <1.0 EU/µg as determined by the LAL method.
Biological Activity : The biological activity of Human TGF-β soluble Receptor III was determined by its ability to inhibit the TGF-β2 mediated response of a mouse T cell line, HT-2 (Tsang, M. et al., 1995, Cytokine 7:389). The expected ED50 is approximately 20 - 50 ng/mL to inhibit 50% of the biological response due to 0.4 ng/mL of TGF-β2.
Storage And Stability : This lyophilized protein is stable for six to twelve months when stored desiccated at -20℃ to -70℃. After aseptic reconstitution, this protein may be stored at 2℃ to 8℃ for one month or at -20℃ to -70℃ in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name : TGFBR3 transforming growth factor, beta receptor III [ Homo sapiens ]
Synonyms : TGFBR3; transforming growth factor, beta receptor III; BGCAN; betaglycan; betaglycan proteoglycan; transforming growth factor, beta receptor III (betaglycan, 300kDa); TGF-beta receptor type III; TGFR-3
Gene ID : 7049
mRNA Refseq : NM_003243
Protein Refseq : NP_003234
MIM : 600742
UniProt ID : Q03167
Chromosome Location : 1p33-p32
Function : PDZ domain binding; SMAD binding; coreceptor activity; heparin binding; transforming growth factor beta binding; transforming growth factor beta receptor activity, type III; type II transforming growth factor beta receptor binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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What are the implications of TGFBR3 mutations in the context of hereditary connective tissue disorders? 03/05/2022

TGFBR3 mutations are associated with hereditary connective tissue disorders, impacting extracellular matrix homeostasis and contributing to conditions like Loeys-Dietz syndrome.

How does TGFBR3 influence embryonic development, and what are the consequences of its dysregulation during development? 04/26/2021

TGFBR3 plays a role in embryonic development, and dysregulation may lead to developmental abnormalities due to disrupted TGF-beta signaling.

Can you explain the role of TGFBR3 in mediating interactions between cells and extracellular matrix components? 07/15/2019

TGFBR3 facilitates cell-ECM interactions by modulating TGF-beta signaling, influencing processes like cell adhesion and migration.

How does TGFBR3 contribute to the modulation of TGF-beta signaling pathways? 05/24/2018

TGFBR3 acts as a co-receptor, enhancing the binding of TGF-beta ligands to TGF-beta receptors, and modulates downstream signaling events.

What are the functional consequences of TGFBR3 mutations in the context of cardiovascular diseases? 02/11/2018

TGFBR3 mutations are implicated in cardiovascular diseases, affecting TGF-beta-mediated processes in vascular smooth muscle cells and cardiac tissues.

Customer Reviews (3)

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Reviews
05/10/2022

    Great product !

    02/18/2020

      Seamless delivery process—ordered, received, and ready for experiments.

      08/31/2018

        Timely delivery is key, and this product arrived on schedule.

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