| Cat.No. : |
PDE4A-29933TH |
| Product Overview : |
Recombinant full length Human PDE4A, isoform 4 with N terminal proprietary tag. Predicted MW 97.24 kDa. |
| Description : |
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| Protein length : |
647 amino acids |
| Molecular Weight : |
97.240kDa inclusive of tags |
| Source : |
Wheat germ |
| Tissue specificity : |
Isoform 1 is widely expressed. Isoform 2 is abundant in liver, stomach, testis, thyroid and adrenal glands. It is also found in placenta, kidney, pancreas, ovary, uterus, skin, monocytes, mast cells, macrophages, as well as in bronchial smooth muscle. Iso |
| Form : |
Liquid |
| Purity : |
Proprietary Purification |
| Storage : |
Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
| Sequences of amino acids : |
MPLVDFFCET CSKPWLVGWW DQFKRMLNRE LTHLSEMSRS GNQVSEYIST TFLDKQNEVE IPSPTMKERE KQQAPRPRPS QPPPPPVPHL QPMSQITGLK KLMHSNSLNN SNIPRFGVKT DQEELLAQEL ENLNKWGLNI FCVSDYAGGR SLTCIMYMIF QERDLLKKFR IPVDTMVTYM LTLEDHYHAD VAYHNSLHAA DVLQSTHVLL ATPALDAVFT DLEILAALFA AAIHDVDHPG VSNQFLINTN SELALMYNDE SVLENHHLAV GFKLLQEDNC DIFQNLSKRQ RQSLRKMVID MVLATDMSKH MTLLADLKTM VETKKVTSSG VLLLDNYSDR IQVLRNMVHC ADLSNPTKPL ELYRQWTDRI MAEFFQQGDR ERERGMEISP MCDKHTASVE KSQVGFIDYI VHPLWETWAD LVHPDAQEIL DTLEDNRDWY YSAIRQSPSP PPEEESRGPG HPPLPDKFQF ELTLEEEEEE EISMAQIPCT AQEALTAQGL SGVEEALDAT IAWEASPAQE SLEVMAQEAS LEAELEAVYL TQQAQSTGSA PVAPDEFSSR EEFVVAVSHS SPSALALQSP LLPAWRTLSV SEHAPGLPGL PSTAAEVEAQ REHQAAKRAC SACAGTFGED TSALPAPGGG GSGGDPT |
| Sequence Similarities : |
Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily. |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.