Recombinant Human PDE4A
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Cat.No. : | PDE4A-29933TH |
Product Overview : | Recombinant full length Human PDE4A, isoform 4 with N terminal proprietary tag. Predicted MW 97.24 kDa. |
Description : | The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
Protein length : | 647 amino acids |
Molecular Weight : | 97.240kDa inclusive of tags |
Source : | Wheat germ |
Tissue specificity : | Isoform 1 is widely expressed. Isoform 2 is abundant in liver, stomach, testis, thyroid and adrenal glands. It is also found in placenta, kidney, pancreas, ovary, uterus, skin, monocytes, mast cells, macrophages, as well as in bronchial smooth muscle. Iso |
Form : | Liquid |
Purity : | Proprietary Purification |
Storage : | Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles. |
Sequences of amino acids : | MPLVDFFCET CSKPWLVGWW DQFKRMLNRE LTHLSEMSRS GNQVSEYIST TFLDKQNEVE IPSPTMKERE KQQAPRPRPS QPPPPPVPHL QPMSQITGLK KLMHSNSLNN SNIPRFGVKT DQEELLAQEL ENLNKWGLNI FCVSDYAGGR SLTCIMYMIF QERDLLKKFR IPVDTMVTYM LTLEDHYHAD VAYHNSLHAA DVLQSTHVLL ATPALDAVFT DLEILAALFA AAIHDVDHPG VSNQFLINTN SELALMYNDE SVLENHHLAV GFKLLQEDNC DIFQNLSKRQ RQSLRKMVID MVLATDMSKH MTLLADLKTM VETKKVTSSG VLLLDNYSDR IQVLRNMVHC ADLSNPTKPL ELYRQWTDRI MAEFFQQGDR ERERGMEISP MCDKHTASVE KSQVGFIDYI VHPLWETWAD LVHPDAQEIL DTLEDNRDWY YSAIRQSPSP PPEEESRGPG HPPLPDKFQF ELTLEEEEEE EISMAQIPCT AQEALTAQGL SGVEEALDAT IAWEASPAQE SLEVMAQEAS LEAELEAVYL TQQAQSTGSA PVAPDEFSSR EEFVVAVSHS SPSALALQSP LLPAWRTLSV SEHAPGLPGL PSTAAEVEAQ REHQAAKRAC SACAGTFGED TSALPAPGGG GSGGDPT |
Sequence Similarities : | Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily. |
Gene Name : | PDE4A phosphodiesterase 4A, cAMP-specific [ Homo sapiens ] |
Official Symbol : | PDE4A |
Synonyms : | PDE4A; phosphodiesterase 4A, cAMP-specific; DPDE2, phosphodiesterase 4A, cAMP specific (dunce (Drosophila) homolog phosphodiesterase E2); cAMP-specific 3,5-cyclic phosphodiesterase 4A; phosphodiesterase E2 dunce homolog (Drosophila); |
Gene ID : | 5141 |
mRNA Refseq : | NM_001111307 |
Protein Refseq : | NP_001104777 |
MIM : | 600126 |
Uniprot ID : | P27815 |
Chromosome Location : | 19p13.2 |
Pathway : | DARPP-32 events, organism-specific biosystem; G Protein Signaling Pathways, organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; Opioid Signalling, organism-specific biosystem; |
Function : | 3,5-cyclic-AMP phosphodiesterase activity; hydrolase activity; metal ion binding; phosphoric diester hydrolase activity; protein binding; |
◆ Recombinant Protein
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PDE4A-1527H | Recombinant Human PDE4A (Active), GST-tagged | +Inquiry |
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◆ Lysates
PDE4A-3352HCL | Recombinant Human PDE4A 293 Cell Lysate | +Inquiry |
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◆ Assay kits
Kit-1838 | PDE4A Assay Kit | +Inquiry |
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Pde10a PDE11A PDE1A PDE1B Pde1c PDE2A PDE3A PDE3B PDE4A PDE4B PDE4C PDE4D PDE5A PDE6B PDE6C PDE6D PDE7A PDE7B PDE8A PDE9A PDE4DIP PDE12 PDE6A PDE8B PDE6G PDE6H
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