"ROCK2" Related Products

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Recombinant Human ROCK2

Cat.No.: ROCK2-30955TH
Product Overview: Recombinant fusion protein, corresponding to amino acids 5-554 of Human ROCK2 with an N-terminal tag, expressed by baculovirus in Sf9 insect cells.
Description: The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.
Biological activity: Specific activity 350 nmol/min/mg.
Form: Liquid
Storage buffer: Preservative: NoneConstituents: 25% Glycerol, 50mM Tris HCl, 150mM Sodium chloride, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, pH 7.5
Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
Sequence Similarities: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.Contains 1 AGC-kinase C-terminal domain.Contains 1 PH domain.Contains 1 phorbol-ester/DAG-type zinc finger.Contains 1 protein kinase domain.Contains 1 REM (Hr1) repeat.
Gene Name: ROCK2 Rho-associated, coiled-coil containing protein kinase 2 [ Homo sapiens ]
Official Symbol: ROCK2
Synonyms: ROCK2; Rho-associated, coiled-coil containing protein kinase 2; rho-associated protein kinase 2;
Gene ID: 9475
mRNA Refseq: NM_004850
Protein Refseq: NP_004841
MIM: 604002
Uniprot ID: O75116
Chromosome Location: 2p24
Pathway: Axon guidance, organism-specific biosystem; Axon guidance, conserved biosystem; Axon guidance, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem;
Function: ATP binding; metal ion binding; nucleotide binding; protein binding; protein serine/threonine kinase activity;

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