"TIMP1" Related Products

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Recombinant Rat TIMP Metallopeptidase Inhibitor 1

Cat. No.: Timp1-1798R
Description: Tissue Inhibitor of Metalloproteinases 1, also known as TIMP1 is a widely expressed, secreted protein that functions primarily to inhibit members of a large family of metalloproteinases (MPs). Because of the ability of TIMP-1 to inhibit MPs, it functions in many of the same pathophysiological processes as these enzymes, e.g. wound healing, ovulation, angiogenesis, and cancer cell metastasis. TIMP-1 can also stimulate proliferation and cellular anabolic processes. TIMP-1 is a novel negative regulator of HGF activity during liver regeneration. Overexpression of TIMP-1 could promote renal interstitial fibrosis through the inflammatory pathway, which might be partly induced by upregulating ICAM-1.
Source: NSO Cells.
Molecular Weight: The predicted molecular weight of Recombinant Rat TIMP-1 is Mr 21.5 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 32-34 kDa.
State Of Matter: Lyophilized.
Purity: >95% by SDS Page and analyzed by silver stain.
Endotoxin: <1.0 EU/µg as determined by the LAL method.
Storage And Stability: This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Gene Name: Timp1 TIMP metallopeptidase inhibitor 1 [ Rattus norvegicus ]
Synonyms: Timp1; TIMP metallopeptidase inhibitor 1; Timp; TIMP-1; tissue inhibitor of metallopeptidase 1
Gene ID: 116510
mRNA Refseq: NM_053819
Protein Refseq: NM_053819
UniProt ID: P30120
Chromosome Location: Xq12
Function: metalloendopeptidase inhibitor activity; protein binding

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