Recombinant Human ADAM Metallopeptidase Domain 17, His-tagged
Cat.No. : | ADAM17-592H |
Product Overview : | Recombinant human glycosylated catalytic domain (aa Pro1-Val477) of ADAM17/TACE secreted as mature, active enzyme frominsect cells,and purified using a C-terminal His-tag, 36kDa. |
- Specification
- Gene Information
- Related Products
Cat. No. : | ADAM17-592H |
Description : | ADAM17/TACE is a soluble or membrane-bound metalloproteinase primarily responsible for activation of proTNF-α, while also targeting proteins such as fractalkine, amyloid precursor proteins, and CD40. ADAM17/TACE is involved in cancer, vascular disorders, and inflammatory diseases such as rheumatoid arthritis and focal ischemic injury. The catalytic domain of ADAM17/TACE is able to cleave proTNF-α and can be used in inhibitor screening. |
Source : | insect cells. |
Concentration : | 0.45 µg/µl. |
Purity : | ≥90% (SDS-PAGE). |
Formulation : | Liquid. In 22.5mM TRIS, pH 7.5, containing 4.5µM ZnCl2, 0.0045% Brij-35 and 10% glycerol. |
Specific Activity: : | 2'430 U/µg enzyme. One unit will hydrolyze one pmole Mca-PLAQAV-Dpa-RSSSR-NH2 substrate (10µM) per minute at 37°C, in 25mM TRIS, pH 9.0. |
Application : | Study enzyme kinetics, cleave target substrates, screen inhibitors. |
Storage : | Avoid freeze/thaw cycles. After opening, prepare aliquots and store at -80°C. |
Pathways : | Alzheimer"s disease; Epithelial cell signaling in Helicobacter pylori infection; Notch signaling pathway; Signaling by EGFR; Signalling by NGF |
Gene Name : | ADAM17 ADAM metallopeptidase domain 17 [ Homo sapiens ] |
Synonyms : | ADAM metallopeptidase domain 17; CSVP; TACE; ADAM18; CD156B; MGC71942; ADAM17; disintegrin and metalloproteinase domain-containing protein 17; ADAM 17; EC 3.4.24.86; TNF-alpha convertase; snake venom-like protease; TNF-alpha converting enzyme; TNF-alpha-converting enzyme; ADAM metallopeptidase domain 18;tumor necrosis factor, alpha, converting enzyme; a disintegrin and metalloprotease domain 17; CD156b antigen |
Gene ID : | 6668 |
mRNA Refseq : | NM_003183 |
Protein Refseq : | NP_003174 |
MIM : | 603639 |
UniProt ID : | P78536 |
Chromosome Location : | 2p25 |
Function : | PDZ domain binding; SH3 domain binding; integrin binding; interleukin-6 receptor binding; metal ion binding; metalloendopeptidase activity; metalloendopeptidase activity; metallopeptidase activity; peptidase activity; protein binding; zinc ion binding |
Products Types
◆ Recombinant Protein | ||
ADAM17-073R | Recombinant Rat ADAM17 Protein, His-tagged | +Inquiry |
ADAM17-085M | Recombinant Mouse ADAM17 Protein, His-tagged | +Inquiry |
Adam17-8788R | Active Recombinant Rat Adam17 protein(Met1-Asp563), His-tagged | +Inquiry |
ADAM17-157R | Recombinant Rat ADAM17 Protein, His (Fc)-Avi-tagged | +Inquiry |
Adam17-308M | Recombinant Mouse Adam17 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
ADAM17-1198RCL | Recombinant Rat ADAM17 cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-0049 | ADAM17 Inhibitor Screening Assay Kit | +Inquiry |
Kit-0048 | ADAM17 fluorometric drug discovery Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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