Recombinant Human Calcyclin Binding Protein CACYBP-2533H

Recombinant Human Calcyclin Binding Protein

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Recombinant Human Calcyclin Binding Protein

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Cat. No. : CACYBP-2533H
Description : CACYBP is primarily a nuclear protein that contains one CS domain and one SGS domain. It is believed to be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It most likely serves as a molecular bridge in Ubiquitin E3 complexes. It also participates in the Ubiquitin-mediated degradation of β-catenin. CACYBP is thought to be a potential inhibitor of cell growth and invasion in the gastric cancer cell through its effects on β-catenin protein expression and transcriptional activation of TCF/LEF.
Source : E.coli.
Biochem/physiol Actions : Calcyclin binding protein (CACYBP), highly expressed in brain neurons, is involved in calcium-dependent ubiquitination and proteosomal degradation of target proteins. CACYBP serves as an adaptor protein in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of β-catenin. CACYBP is also involved in cell growth inhibition and cell differentiation. CACYBP is a potential inhibitor of cell growth and invasion of gastric cancer cells. Overexpression of CACYBP leads to the suppression of growth in renal cell carcinoma.
Physical Form : Solution in 20 mM Tris, pH 7.6, containing 1 mM EDTA, 1 mM DTT, and 30% glycerol (v/v).
Assay : ≥90% (SDS-PAGE).
Form : buffered aqueous solution.
Mol Wt : mol wt 30 kDa.
Storage Temp : −20°C.
PDB rendering based on 1x5m. :

Gene Name : CACYBP calcyclin binding protein [ Homo sapiens ]
Synonyms : calcyclin binding protein; SIP; GIG5; MGC87971; PNAS-107; S100A6BP; RP1-102G20.6; CACYBP; calcyclin-binding protein; hCacyBP; S100A6-binding protein; Siah-interacting protein (SIP); growth-inhibiting gene 5 protein;OTTHUMP00000201857; Siah-interacting protein; CacyBP
Gene ID : 27101
mRNA Refseq : NM_001007214
Protein Refseq : NP_001007215
MIM : 606186
UniProt ID : Q9HB71
Chromosome Location : 1q24-q25
Pathway : Wnt signaling pathway
Function : protein binding; protein homodimerization activity

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