Recombinant Human Calcyclin Binding Protein

• Cat.No.: CACYBP-2533H

Specification

• Cat. No.: CACYBP-2533H
• Description: CACYBP is primarily a nuclear protein that contains one CS domain and one SGS domain. It is believed to be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It most likely serves as a molecular bridge in Ubiquitin E3 complexes. It also participates in the Ubiquitin-mediated degradation of β-catenin. CACYBP is thought to be a potential inhibitor of cell growth and invasion in the gastric cancer cell through its effects on β-catenin protein expression and transcriptional activation of TCF/LEF.
• Source: E.coli.
• Biochem/physiol Actions: Calcyclin binding protein (CACYBP), highly expressed in brain neurons, is involved in calcium-dependent ubiquitination and proteosomal degradation of target proteins. CACYBP serves as an adaptor protein in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of β-catenin. CACYBP is also involved in cell growth inhibition and cell differentiation. CACYBP is a potential inhibitor of cell growth and invasion of gastric cancer cells. Overexpression of CACYBP leads to the suppression of growth in renal cell carcinoma.
• Physical Form: Solution in 20 mM Tris, pH 7.6, containing 1 mM EDTA, 1 mM DTT, and 30% glycerol (v/v).
• Assay: ≥90% (SDS-PAGE).
• Form: buffered aqueous solution.
• Mol Wt: mol wt 30 kDa.
• Storage Temp: −20°C.

Gene Information

• Gene Name: CACYBP calcyclin binding protein [ Homo sapiens ]
• Synonyms: calcyclin binding protein; SIP; GIG5; MGC87971; PNAS-107; S100A6BP; RP1-102G20.6; CACYBP; calcyclin-binding protein; hCacyBP; S100A6-binding protein; Siah-interacting protein (SIP); growth-inhibiting gene 5 protein;OTTHUMP00000201857; Siah-interacting protein; CacyBP
• Gene ID: 27101
• mRNA Refseq: NM_001007214
• Protein Refseq: NP_001007215
• MIM: 606186
• UniProt ID: Q9HB71
• Chromosome Location: 1q24-q25
• Pathway: Wnt signaling pathway
• Function: protein binding; protein homodimerization activity