Recombinant Full Length Human FGF23 Protein, C-His-tagged
Cat.No. : | FGF23-299H |
Product Overview : | Recombinant Full Length Human FGF23 Protein, fused to His-tag at C-terminus, was expressed in HEK293T. |
- Specification
- Gene Information
- Related Products
Description : | FGF-23 (Fibroblast growth factor 23) is a regulator of phosphate homeostasis. It upregulates EGR1 expression in the presence of KLBy. Acts directly on the parathyroid to decrease PTH secretion. Regulates the vitamin D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization. Defects in FGF-23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR) and of hyperphosphatemic familial tumoral calcinosis (HFTC). |
Source : | HEK293T |
Species : | Human |
Tag : | C-His |
Protein length : | 1-251 aa |
Form : | Lyophilized. Contains PBS. |
Bio-activity : | Activates ERK and FRS2α phosphorylation in Klotho expressing cells. |
Molecular Mass : | ~30kDa (SDS-PAGE, full-length). FGF23 is cleaved between Arg179 and Ser180 (two bands of ~14kDa and ~16kDa). |
Endotoxin : | <0.01EU/μg purified protein (LAL test; Lonza). |
Purity : | ≥90% (SDS-PAGE) |
Storage : | Short Term Storage: 4 centigrade Long Term Storage: -20 centigrade |
Shipping : | BLUE ICE |
Handling Advice : | After reconstitution, prepare aliquots and store at -20 centigrade. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1% BSA should be used for further dilutions. |
Use/Stability : | Stable for at least 6 months after receipt when stored at -20 centigrade. Working aliquots are stable for up to 3 months when stored at -20 centigrade. |
Reconstitution : | Reconstitute with 100μl sterile water. |
References : | 1. Maternally-derived antibody to fibroblast growth factor-23 reduced dietary phosphate requirements in growing chicks: E.A. Bobeck, et al.; BBRC 420, 666 (2012) 2. Antibody to fibroblast growth factor 23-peptide reduces excreta phosphorus of laying hens: Z. Ren, et al.; Poultry Science 96, 127 (2017). |
Gene Name : | FGF23 fibroblast growth factor 23 [ Homo sapiens (human) ] |
Official Symbol : | FGF23 |
Synonyms : | FGF23; fibroblast growth factor 23; Fibroblast Growth Factor 23; Tumor-derived Hypophosphatemia-inducing Factor; ADHR; FGFN; HYPF; HFTC2; HPDR2; PHPTC |
Gene ID : | 8074 |
mRNA Refseq : | NM_020638.3 |
Protein Refseq : | NP_065689.1 |
MIM : | 605380 |
UniProt ID : | Q9GZV9 |
Products Types
◆ Recombinant Protein | ||
FGF23-1492H | Recombinant Human FGF23 Protein, His&GST-tagged | +Inquiry |
FGF23-908H | Recombinant Human FGF23 Protein, His (Fc)-Avi-tagged | +Inquiry |
Fgf23-2998M | Recombinant Mouse Fgf23 Protein, Myc/DDK-tagged | +Inquiry |
FGF23-1014H | Recombinant Human FGF23 Protein (Y25-R179), His tagged | +Inquiry |
FGF23-036H | Active Recombinant Human FGF23 Protein | +Inquiry |
◆ Lysates | ||
FGF23-6241HCL | Recombinant Human FGF23 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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