Recombinant Full Length Human FGF23 Protein, C-Flag-tagged

• Cat.No.: FGF23-1113HFL
• Product Overview: Recombinant Full Length Human FGF23 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the fibroblast growth factor family of proteins, which possess broad mitogenic and cell survival activities and are involved in a variety of biological processes. The product of this gene regulates phosphate homeostasis and transport in the kidney. The full-length, functional protein may be deactivated via cleavage into N-terminal and C-terminal chains. Mutation of this cleavage site causes autosomal dominant hypophosphatemic rickets (ADHR). Mutations in this gene are also associated with hyperphosphatemic familial tumoral calcinosis (HFTC).
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 25.3 kDa
• AA Sequence: MLGARLRLWVCALCSVCSMSVLRAY PNASPLLGSSWGGLIHLYTATARNS YHLQIHKNGHVDGAPHQTIY SALMIRSEDAGFVVITGVMSRRYLC MDFRGNIFGSHYFDPENCRFQHQTL ENGYDVYHSPQYHFLVSLGR AKRAFLPGMNPPPYSQFLSRRNEIP LIHFNTPIPRRHTRSAEDDSERDPL NVLKPRARMTPAPASCSQEL
  PSAEDNSPMASDPLGVVRGGRVNTH AGGTGPEGCRPFAKFITRTRPLEQK LISEEDLAANDILDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Secreted Protein
• Protein Pathways: MAPK signaling pathway, Melanoma, Pathways in cancer, Regulation of actin cytoskeleton

Gene Information

• Gene Name: FGF23 fibroblast growth factor 23 [ Homo sapiens (human) ]
• Official Symbol: FGF23
• Synonyms: ADHR; FGFN; HYPF; HFTC2; HPDR2; PHPTC
• Gene ID: 8074
• mRNA Refseq: NM_020638.3
• Protein Refseq: NP_065689.1
• MIM: 605380
• UniProt ID: Q9GZV9