Recombinant Full Length Human SPN Protein, C-Flag-tagged

• Cat.No.: SPN-1075HFL
• Product Overview: Recombinant Full Length Human SPN Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a highly sialylated glycoprotein that functions in antigen-specific activation of T cells, and is found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It contains a mucin-like extracellular domain, a transmembrane region and a carboxy-terminal intracellular region. The extracellular domain has a high proportion of serine and threonine residues, allowing extensive O-glycosylation, and has one potential N-glycosylation site, while the carboxy-terminal region has potential phosphorylation sites that may mediate transduction of activation signals. Different glycoforms of this protein have been described. In stimulated immune cells, proteolytic cleavage of the extracellular domain occurs in some cell types, releasing a soluble extracellular fragment. Defects in expression of this gene are associated with Wiskott-Aldrich syndrome.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 40.1 kDa
• AA Sequence: MATLLLLLGVLVVSPDALGSTTAVQ TPTSGEPLVSTSEPLSSKMYTTSIT SDPKADSTGDQTSALPPSTS INEGSPLWTSIGASTGSPLPEPTTY QEVSIKMSSVPQETPHATSHPAVPI TANSLGSHTVTGGTITTNSP ETSSRTSGAPVTTAASSLETSRGTS GPPLTMATVSLETSKGTSGPPVTMA TDSLETSTGTTGPPVTMTTG SLEPSSGASGPQVSSVKLSTMMSPT TSTNASTVPFRNPDENSRGMLPVAV LVALLAVIVLVALLLLWRRR QKRRTGALVLSRGGKRNGVVDAWAG PAQVPEEGAVTVTVGGSGGDKGSGF PDGEGSSRRPTLTTFFGRRK
  SRQGSLAMEELKSGSGPSLKGEEEP LVASEDGAVDAPAPDEPEGGDGAAP TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
• Protein Pathways: Cell adhesion molecules (CAMs)

Gene Information

• Gene Name: SPN sialophorin [ Homo sapiens (human) ]
• Official Symbol: SPN
• Synonyms: LSN; CD43; GALGP; GPL115; LEU-22
• Gene ID: 6693
• mRNA Refseq: NM_003123.6
• Protein Refseq: NP_003114.1
• MIM: 182160
• UniProt ID: P16150

Reviews

06/23/2023

Accurate and timely results, crucial for research progress.

10/02/2018

Instrumental in our research achievements, highly trusted.

03/26/2018

Efficient and dependable, aids our research significantly.

Q&As

What is the primary role of SPN in immune cell function?

SPN, or Sialophorin, is important in modulating the function of immune cells, particularly lymphocytes.

What potential therapeutic applications arise from targeting SPN in immune disorders?

Targeting SPN could provide new treatment approaches for managing immune-related conditions, including autoimmune diseases.

How do genetic variations in SPN affect immune response?

Genetic changes in SPN can lead to variations in immune cell behavior and effectiveness.

What role does SPN play in cell adhesion and migration?

SPN plays a role in regulating immune cell adhesion and migration, crucial for immune surveillance and response.

How does SPN interact with other components of the immune system?

SPN interacts with other immune molecules, coordinating immune cell communication and function.

What is the impact of altered SPN activity on autoimmune diseases?

Altered SPN activity can impact the regulation of immune responses, potentially leading to autoimmune disorders.

How does SPN contribute to immune cell signaling?

It contributes to immune cell signaling, influencing cell activation and response to stimuli.