Recombinant Human Fibroblast Growth Factor 23, Fc Chimera

• Cat.No.: FGF23-416H
• Product Overview: Recombinant human FGF-23 (aa 1-251) produced inHEK 293 cellsare fused at the C-terminus to the Fc portion of human IgG.

Specification

• Cat. No.: FGF23-416H
• Description: FGF-23 is a member of the fibroblast growth factor (FGF) family. FGF-23 inhibits renal tubular phosphate transport. This gene was identified by its mutations associated with autosomal dominant hypophosphatemic rickets (ADHR), an inherited phosphate wasting disorder. Abnormally high level expression of FGF23 was found in oncogenic hypophosphatemic osteomalacia (OHO), a phenotypically similar disease caused by abnormal phosphate metabolism. Mutations FGF23 have also been shown to cause familial tumoral calcinosis with hyperphosphatemia.
• Source/Host: HEK 293 cells.
• Purity: ≥90% (SDS-PAGE).
• Formulation: Liquid. 0.2μm-filtered solution in PBS.
• Concentration: 1mg/ml.
• Endotoxin Content: <1EU/µg protein (LAL-test).
• Long Term Storage: -20°C.
• Use/Stability: Working aliquots are stable for up to 3 months when stored at -20°C.
• Handling: After opening, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
• Protein length: 1-251

Gene Information

• Gene Name: FGF23 fibroblast growth factor 23 [ Homo sapiens ]
• Synonyms: FGF23; fibroblast growth factor 23; ADHR; HYPF; HPDR2; PHPTC; FGF-23; Tumor-derived hypophosphatemia-inducing factor; Phosphatonin; UNQ3027/PRO9828; Fibroblast growth factor 23 N-terminal peptide; Fibroblast growth factor 23 C-terminal peptide; tumor-derived hypophosphatemia inducing factor
• Gene ID: 8074
• mRNA Refseq: NM_020638
• Protein Refseq: NP_065689
• MIM: 605380
• UniProt ID: Q9GZV9
• Chromosome Location: 12p13.3
• Pathway: MAPK signaling pathway; Melanoma; Pathways in cancer; Regulation of actin cytoskeleton; Signaling by FGFR
• Function: growth factor activity

Reviews

07/23/2022

Excellent results, high purity.

07/17/2021

Reliable and effective product.

11/26/2020

Quick delivery, product works.

Q&As

What role does FGF23 play in chronic kidney disease?

FGF23 levels are elevated in chronic kidney disease, contributing to mineral imbalance.

How is FGF23 implicated in cardiovascular health?

High FGF23 levels are associated with increased cardiovascular risk.

How does FGF23 regulate phosphate and calcium homeostasis?

It decreases renal phosphate reabsorption and 1,25-dihydroxyvitamin D production.

Are there known genetic mutations that affect FGF23 production or activity?

Mutations in FGF23 or related proteins can lead to dysregulated phosphate metabolism.

What therapeutic strategies are being explored to modulate FGF23 levels?

Strategies include phosphate binders and FGF23 antibodies to manage elevated FGF23 levels.

In which tissues is FGF23 predominantly produced and secreted?

FGF23 is primarily produced in bone.

What is the primary function of FGF23 in the body?

FGF23 regulates phosphate and vitamin D metabolism.