Recombinant Human IGF1 protein, Fc-tagged
Cat.No. : | IGF1-384H |
Product Overview : | Recombinant Human IGF1 protein (Gly49-Ala118), fused to human IgG1 Fc tag at N-terminus, was expressed in human 293 cells (HEK293). |
- Specification
- Gene Information
- Related Products
Description : | Insulin-like growth factor 1 (IGF-1) is also known as somatomedin C, IGF1A, IGFI, sulfation factor, and is a hormone similar in molecular structure to insulin. It plays an important role in childhood growth and continues to have anabolic effects in adults. A synthetic analog of IGF-1, mecasermin is used for the treatment of growth failure. IGF-1 consists of 70 amino acids in a single chain with three intramolecular disulfide bridges. IGF-1 has a molecular weight of 7649 daltons. IGF-1 is produced primarily by the liver as an endocrine hormone as well as in target tissues in a paracrine/autocrine fashion. IGF-1 binds to at least two cell surface receptors: the Insulin-like growth factor 1 receptor, abbreviated as "IGF1R", and the insulin receptor. The IGF-1 receptor seems to be the "physiologic" receptor - it binds IGF-1 at significantly higher affinity than the IGF-1 that is bound to the insulin receptor. Like the insulin receptor, the IGF-1 receptor is a receptor tyrosine kinase - meaning it signals by causing the addition of a phosphate molecule on particular tyrosines. Its primary action is mediated by binding to its specific receptor IGF1R, present on many cell types in many tissues. Binding to the IGF1R, a receptor tyrosine kinase, initiates intracellular signaling; IGF-1 is one of the most potent natural activators of the AKT signaling pathway, a stimulator of cell growth and proliferation, and a potent inhibitor of programmed cell death. Insulin-like growth factor 1 has been shown to bind and interact with all the IGF-1 Binding Proteins (IGFBPs), of which there are six (IGFBP1-6). Specific references are provided for interactions with IGFBP3, IGFBP4 and IGFBP7. |
Source : | HEK293 |
Species : | Human |
Tag : | human IgG1 Fc |
Form : | Lyophilized from 0.22 um filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 35.0 kDa. The protein migrates as 40 kDa under reducing (R) condition (SDS-PAGE). |
Protein length : | 70 |
Endotoxin : | Less than 1.0 EU per ug by the LAL method. |
Purity : | >98% as determined by SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 centigrade to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | IGF1 |
Official Symbol : | IGF1 |
Synonyms : | IGF1; insulin-like growth factor 1 (somatomedin C); insulin-like growth factor 1; IGF1A; MGF; IGF-IA; IGF-IB; somatomedin-C; mechano growth factor; insulin-like growth factor I; insulin-like growth factor IA; insulin-like growth factor IB; IGFI; IGF-I |
Gene ID : | 3479 |
mRNA Refseq : | NM_000618 |
Protein Refseq : | NP_000609 |
MIM : | 147440 |
UniProt ID : | P05019 |
Products Types
◆ Recombinant Protein | ||
IGF1-4460M | Recombinant Mouse IGF1 Protein, His (Fc)-Avi-tagged | +Inquiry |
IGF1-376I | Active Recombinant Human IGF1 Protein (70 aa) | +Inquiry |
IGF1-126H | Recombinant Active Human IGF1 Protein, Fc-His-tagged(C-ter) | +Inquiry |
IGF1-210P | Recombinant Pig IGF1 Protein (Gly49-Ala118), C-His tagged, Animal-free, Carrier-free | +Inquiry |
IGF1-119H | Active Recombinant Human IGF1 Protein | +Inquiry |
◆ Lysates | ||
IGF1-5268HCL | Recombinant Human IGF1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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