Recombinant Human MAPK8 Protein, Myc/DDK-tagged, C13 and N15-labeled
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| Cat.No. : | MAPK8-1729H |
| Product Overview : | MAPK8 MS Standard C13 and N15-labeled recombinant protein (NP_620637) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
| Description : | The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. |
| Source : | HEK293 |
| Species : | Human |
| Tag : | Myc/DDK |
| Molecular Mass : | 48.1 kDa |
| AA Sequence : | MSRSKRDNNF YSVEIGDSTF TVLKRYQNLK PIGSGAQGIV CAAYDAILER NVAIKKLSRP FQNQTHAKRA YRELVLMKCV NHKNIIGLLN VFTPQKSLEE FQDVYIVMEL MDANLCQVIQ MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF MMTPYVVTRY YRAPEVILGM GYKENVDLWS VGCIMGEMVC HKILFPGRDY IDQWNKVIEQ LGTPCPEFMK KLQPTVRTYV ENRPKYAGYS FEKLFPDVLF PADSEHNKLK ASQARDLLSK MLVIDASKRI SVDEALQHPY INVWYDPSEA EAPPPKIPDK QLDEREHTIE EWKELIYKEV MDLEERTKNG VIRGQPSPLG AAVINGSQHP SSSSSVNDVS SMSTDPTLAS DTDSSLEAAA GPLGCCRTRT RPLEQKLISE EDLAANDILD YKDDDDKV |
| Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : | 50 μg/mL as determined by BCA |
| Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
| SDS-PAGE : |
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| Gene Name : | MAPK8 mitogen-activated protein kinase 8 [ Homo sapiens (human) ] |
| Official Symbol : | MAPK8 |
| Synonyms : | MAPK8; mitogen-activated protein kinase 8; PRKM8; JNK; JNK1; JUN N terminal kinase; SAPK1; MAP kinase 8; JUN N-terminal kinase; c-Jun N-terminal kinase 1; stress-activated protein kinase 1; stress-activated protein kinase 1c; mitogen-activated protein kinase 8 isoform JNK1 beta2; mitogen-activated protein kinase 8 isoform JNK1 alpha1; JNK-46; JNK1A2; SAPK1c; JNK21B1/2; |
| Gene ID : | 5599 |
| mRNA Refseq : | NM_139049 |
| Protein Refseq : | NP_620637 |
| MIM : | 601158 |
| UniProt ID : | P45983 |
◆ Recombinant Protein
| Mapk8-3945M | Recombinant Mouse Mapk8 Protein, Myc/DDK-tagged | +Inquiry |
| MAPK8-554H | Recombinant Human Mitogen-Activated Protein Kinase 8, GST-tagged | +Inquiry |
| MAPK8-100H | Recombinant Human MAPK8, His-tagged | +Inquiry |
| Mapk8-1550M | Recombinant Mouse Mapk8 protein, His & T7-tagged | +Inquiry |
| MAPK8-29668TH | Recombinant Human MAPK8 | +Inquiry |
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◆ Lysates
| MAPK8-4488HCL | Recombinant Human MAPK8 293 Cell Lysate | +Inquiry |
| MAPK8-4489HCL | Recombinant Human MAPK8 293 Cell Lysate | +Inquiry |
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MAPK1MAPK10MAPK11MAPK12MAPK13MAPK14MAPK3MAPK8MAPK9MAPK6MAPK7MAPK4MAPK8IP2MAPK8IP3MAPK15MAPK1IP1LMapk8ip1Mapk1ip1
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