Recombinant Human MERTK protein, His & T7-tagged

Cat.No. : MERTK-1183H
Product Overview : Recombinant Human MERTK aa. (Leu587~Leu858 (Accession # Q12866) fused with N-terminal His & T7 tag was produced in E. coli cells.
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Description : This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).
Source : E. coli
Species : Human
Tag : His&T7
Form : Freeze-dried powder
Molecular Mass : 32kDa as determined by SDS-PAGE reducing conditions.
Protein length : Leu587~Leu858 (Accession # Q12866)
Endotoxin : <1.0EU per 1µg (determined by the LAL method)
Purity : >95%
Characteristic : The isoelectric point is 6.2.
Applications : SDS-PAGE; WB; ELISA; IP.
Stability : The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
Storage : Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
Storage buffer : Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
Reconstitution : Reconstitute in sterile PBS, pH7.2-pH7.4.
Gene Name : MERTK MER proto-oncogene, tyrosine kinase [ Homo sapiens (human) ]
Official Symbol : MERTK
Synonyms : MERTK; MER proto-oncogene, tyrosine kinase; MER; RP38; c-Eyk; c-mer; Tyro12; tyrosine-protein kinase Mer; MER receptor tyrosine kinase; STK kinase; c-mer proto-oncogene tyrosine kinase; proto-oncogene c-Mer; receptor tyrosine kinase MerTK
Gene ID : 10461
mRNA Refseq : NM_006343.2
Protein Refseq : NP_006334.2
UniProt ID : Q12866

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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04/08/2022

    Fast shipping and excellent service. This product is a lab essential.

    06/15/2020

      Highly recommend for quality and prompt delivery.

      03/25/2018

        Exceptional product, outstanding customer service!

        Q&As (5)

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        In cancer biology, how does MERTK contribute to tumor progression and metastasis, and are there potential therapeutic strategies targeting MERTK in cancer treatment? 02/18/2022

        MERTK's involvement in cancer includes promoting tumor cell survival and metastasis. Targeting MERTK is under investigation as a potential therapeutic strategy in cancer treatment.

        How does the Gas6-MERTK signaling axis contribute to cellular processes beyond phagocytosis, and what downstream effectors are activated upon MERTK activation? 07/27/2021

        The Gas6-MERTK signaling axis influences diverse cellular processes, activating downstream effectors such as PI3K/Akt and MAPK pathways. Understanding these signaling events provides insights into MERTK's functional diversity.

        In neurobiology, what is the role of MERTK in microglial phagocytosis and synaptic pruning, and how does this impact neural circuitry development? 03/10/2020

        MERTK is involved in microglial phagocytosis and synaptic pruning, contributing to neural circuitry development. Dysregulation may affect synaptic connectivity, with implications for neurodevelopmental disorders.

        What is the role of MERTK in the regulation of immune responses, and how does its dysregulation contribute to autoimmune disorders and inflammatory diseases? 09/03/2019

        MERTK is involved in immune regulation, influencing inflammatory responses. Dysregulation of MERTK has been implicated in autoimmune disorders, emphasizing its role in maintaining immune homeostasis.

        What experimental techniques are commonly used to study MERTK, including its ligands, downstream signaling pathways, and cellular functions? 12/04/2018

        Techniques such as co-immunoprecipitation, flow cytometry, and advanced imaging methods are commonly used to study MERTK, providing insights into ligand interactions, signaling pathways, and cellular functions.

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