| Description : |
This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. |
| Source : |
HEK293 |
| Species : |
Human |
| Tag : |
Myc/DDK |
| Molecular Mass : |
94.6 kDa |
| AA Sequence : |
MLPFGDKTREMVNAWFAERVHTIPV CKEGIRGHTESCSCPLQQSPRADNS APGTPTRKISASEFDRPLRPIVVKD SEGTVSFLSDSEKKEQMPLTPPRFD HDEGDQCSRLLELVKDISSHLDVTA LCHKIFLHIHGLISADRYSLFLVCE DSSNDKFLISRLFDVAEGSTLEEVS NNCIRLEWNKGIVGHVAALGEPLNI KDAYEDPRFNAEVDQITGYKTQSIL CMPIKNHREEVVGVAQAINKKSGNG GTFTEKDEKDFAAYLAFCGIVLHNA QLYETSLLENKRNQVLLDLASLIFE EQQSLEVILKKIAATIISFMQVQKC TIFIVDEDCSDSFSSVFHMECEELE KSSDTLTREHDANKINYMYAQYVKN TMEPLNIPDVSKDKRFPWTTENTGN VNQQCIRSLLCTPIKNGKKNKVIGV CQLVNKMEENTGKVKPFNRNDEQFL EAFVIFCGLGIQNTQMYEAVERAMA KQMVTLEVLSYHASAAEEETRELQS LAAAVVPSAQTLKITDFSFSDFELS DLETALCTIRMFTDLNLVQNFQMKH EVLCRWILSVKKNYRKNVAYHNWRH AFNTAQCMFAALKAGKIQNKLTDLE ILALLIAALSHDLDHRGVNNSYIQR SEHPLAQLYCHSIMEHHHFDQCLMI LNSPGNQILSGLSIEEYKTTLKIIK QAILATDLALYIKRRGEFFELIRKN QFNLEDPHQKELFLAMLMTACDLSA ITKPWPIQQRIAELVATEFFDQGDR ERKELNIEPTDLMNREKKNKIPSMQ VGFIDAICLQLYEALTHVSEDCFPL LDGCRKNRQKWQALAEQQEKMLING ESGQAKRNTRTRPLEQKLISEEDLA ANDILDYKDDDDKV |
| Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
| Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
| Concentration : |
50 μg/mL as determined by BCA |
| Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
