Recombinant Human PDGFD protein

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Recombinant Human PDGFD protein

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Cat.No. : PDGFD-24H
Product Overview : Recombinant Human PDGFD was expressed in HEK293.
Description : PDGF-DD, also known as platelet-derived growth factor D, IEGF and SCDGFB, is asecreted growth factor belonging to the PDGF/VEGFfamily. It is highly expressed in the heart, pancreas, adrenal glands and ovary. PDGF-DD forms functional homodimers that bind and induce PDGF Rβ homodimers and PDGF Rα/β heterodimers that promote intracellular signaling. This plays an important role in the regulation of cell differentiation, migration and survival. It has also been reported that PDGF-DD can induce monocyte and macrophage recruitment, increase interstitial pressure and facilitate wound healing.
Source : CHO
Species : Human
Form : Lyophilized after extensive dialysis against PBS.
Bio-activity : ED50 < 5 μg/ml, measured in a cell proliferation assay using 3T3 cells.
Molecular Mass : 19-21 kDa, observed by reducing SDS-PAGE.
AA Sequence : SYHDRKSKVD LDRLNDDAKR YSCTPRNYSV NIREELKLANVVFFPRCLLV QRCGGNCGCG TVNWRSCTCN SGKTVKKYHEVLQFEPGHIK RRGRAKTMAL VDIQLDHHER CDCICSSRPPR
Endotoxin : < 0.2 EU/μg, determined by LAL method.
Purity : > 95% as analyzed by SDS-PAGE.
Storage : Lyophilized recombinant human PDGF-DD remains stable up to 6 months at -80 centigradefrom date of receipt. Upon reconstitution, human PDGF-DDshould be stable up to 1 week at 4 centigradeor up to 2 months at -20°C.
Reconstitution : Reconstituted in ddH2O or PBS at 100 μg/ml.
Gene Name : PDGFD platelet derived growth factor D [ Homo sapiens ]
Official Symbol : PDGFD
Synonyms : PDGFD; platelet derived growth factor D; platelet-derived growth factor D; IEGF; MSTP036; SCDGF B; spinal cord derived growth factor B; PDGF-D; iris-expressed growth factor; spinal cord-derived growth factor B; spinal cord-derived growth factor-B; SCDGFB; SCDGF-B; MGC26867;
Gene ID : 80310
mRNA Refseq : NM_025208
Protein Refseq : NP_079484
MIM : 609673
UniProt ID : Q9GZP0
Chromosome Location : 11q22.3
Pathway : Focal Adhesion, organism-specific biosystem; Focal adhesion, organism-specific biosystem; Focal adhesion, conserved biosystem; Gap junction, organism-specific biosystem; Gap junction, conserved biosystem; Melanoma, organism-specific biosystem; Melanoma, conserved biosystem;
Function : growth factor activity;

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