Recombinant Human SDC1 Protein, His-tagged

• Cat.No.: SDC1-188H
• Product Overview: Recombinant Human SDC1, transcript variant 2, fused with His tag at C-terminal was expressed in HEK293.

Specification

• Description: The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-1 expression has been detected in several different tumor types. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same protein.
• Source: HEK293
• Species: Human
• Tag: His
• Form: Lyophilized from a 0.2 µM filtered solution of 20mM PB, 150mM NaCl, pH7.4
• Molecular Mass: 20.39kD
• AA Sequence: QIVATNLPPEDQDGSGDDSDNFSGS GAGALQDITLSQQTPSTWKDTQLLT AIPTSPEPTGLEATAASTSTLPAGE GPKEGEAVVLPEVEPGLTAREQEAT PRPRETTQLPTTHQASTTTATTAQE PATSHPHRDMQPGHHETSTPAGPSQ ADLHTPHTEDGGPSATERAAEDGAS SQLPAAEGSGEQDFTFETSGENTAV VAVEPDRRNQSPVDQGATGASQGLL DRKEVDHHHHHH
• Endotoxin: Endotoxin level is <0.1 ng/µg of protein (<1EU/µg).
• Purity: >95% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 µg/ml. Dissolve the lyophilized protein in 1X PBS. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Gene Information

• Gene Name: SDC1 syndecan 1 [ Homo sapiens ]
• Official Symbol: SDC1
• Synonyms: SDC1; syndecan 1; SDC; syndecan-1; CD138; SYND1; syndecan; syndecan proteoglycan 1; CD138 antigen; heparan sulfate proteoglycan fibroblast growth factor receptor
• Gene ID: 6382
• mRNA Refseq: NM_002997
• Protein Refseq: NP_002988
• MIM: 186355
• UniProt ID: P18827

Reviews

10/14/2023

Each customer has a dedicated customer service to provide one-on-one, specialized service that solved the problem in my experiment.

07/22/2023

High quality product at a good price, a satisfactory shopping experience.

07/13/2023

The product brochure is very detailed and has comprehensive basic information about the SDC1 protein.

Q&As

In which tissues is SDC1 mainly expressed?

SDC1 is predominantly expressed in epithelial tissues.

How is SDC1 linked to the ZEB1 transcription factor?

The ZEB1 transcription factor acts on SDC1 and represses its expression.

How does SDC1 relate to the expression of the tight junction protein E-cadherin?

SDC1 protein expression was positively correlated with E-cadherin protein expression and acted synergistically.

What are the effects of inhibiting SDC1 expression?

Inhibition of SDC1 expression promotes tumor growth, invasion and metastasis.

What diseases is SDC1 involved in?

SDC1 is involved in the study of diseases such as liver cancer, colon cancer and breast cancer.

Where is SDC1 located?

SDC1 is localized to the cell membrane.

What biological processes is SDC1 involved in?

SDC1 is involved in biological processes such as cell proliferation, differentiation, and adhesion.