Recombinant Human TIGIT Protein
Cat.No. : | TIGIT-163H |
Product Overview : | Recombinant Human TIGIT was produced in E. coli. |
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Description : | This gene encodes a member of the PVR (poliovirus receptor) family of immunoglobin proteins. The product of this gene is expressed on several classes of T cells including follicular B helper T cells (TFH). The protein has been shown to bind PVR with high affinity; this binding is thought to assist interactions between TFH and dendritic cells to regulate T cell dependent B cell responses. |
Source : | E. coli |
Species : | Human |
Form : | Liquid. In 50 mM Tris-HCl pH7.5, 200 mM NaCl |
Molecular Mass : | (Theoretical molecular weight)~13kDa |
AA sequence : | HHHHHHSSGLVPRGSHMTGTIETTG NISAEKGGSIILQCHLSSTTAQVTQ VNWEQQDQLLAICNADLGWHISPSF KDRVAPGPGLGLTLQSLTVNDTGEY FCIYHTYPDGTYTGRIFLEVLE |
Purity : | >90% as determined by SEC-HPLC |
Storage : | Short Term Storage at +4 centigrade, Long Term, please prepare aliquots with 20% glycerol and store at -20~-80 centigrade. Avoid freeze/thaw cycles. |
Concentration : | 2 mg/ml |
Gene Name : | TIGIT T cell immunoreceptor with Ig and ITIM domains [ Homo sapiens ] |
Official Symbol : | TIGIT |
Synonyms : | TIGIT; T cell immunoreceptor with Ig and ITIM domains; V set and immunoglobulin domain containing 9 , V set and transmembrane domain containing 3 , VSIG9, VSTM3; T-cell immunoreceptor with Ig and ITIM domains; DKFZp667A205; FLJ39873; V-set and transmembrane domain containing 3; V-set and immunoglobulin domain containing 9; Washington University cell adhesion molecule; V-set and transmembrane domain-containing protein 3; V-set and immunoglobulin domain-containing protein 9; VSIG9; VSTM3; WUCAM; |
Gene ID : | 201633 |
mRNA Refseq : | NM_173799 |
Protein Refseq : | NP_776160 |
MIM : | 612859 |
UniProt ID : | Q495A1 |
Products Types
◆ Recombinant Protein | ||
TIGIT-1144C | Recombinant Cynomolgus TIGIT Protein (Met1-Pro209), HlgG1 Fc-tagged | +Inquiry |
TIGIT-725C | Recombinant Cynomolgus monkey TIGIT Protein | +Inquiry |
TIGIT-5739H | Active Recombinant Human TIGIT protein(Met1-Pro141), His-tagged | +Inquiry |
TIGIT-0802R | Active Recombinant Rat TIGIT protein(Met1-Ala138), hFc-tagged | +Inquiry |
Tigit-731M | Recombinant Mouse Tigit Protein, Fc-tagged | +Inquiry |
◆ Lysates | ||
TIGIT-1420MCL | Recombinant Mouse TIGIT cell lysate | +Inquiry |
TIGIT-2610HCL | Recombinant Human TIGIT cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionTIGIT inhibitors are being studied in a range of cancers, including lung cancer, breast cancer, and melanoma, among others.
TIGIT is being explored as a potential target for treating autoimmune diseases by modulating immune responses to prevent excessive inflammation.
TIGIT is being explored as a potential target for cancer immunotherapy, with drugs designed to block TIGIT and enhance the immune system's ability to attack cancer cells.
TIGIT operates as an immune checkpoint, similar to PD-1 and CTLA-4, but it has distinct mechanisms of action and may regulate different aspects of the immune response.
As with any immunotherapy, potential side effects may include immune-related adverse events such as inflammation in various organs, but the specific profile is still under investigation.
Customer Reviews (3)
Write a reviewWith its well-characterized nature and availability in various formats, the TIGIT protein is an advantageous tool that aids researchers in achieving their scientific goals.
Whether it's troubleshooting issues, optimizing experimental protocols, or providing detailed information about the protein, the manufacturer's support team is dedicated to helping researchers overcome any challenges they may encounter.
The manufacturer also ensures that the TIGIT protein is well-characterized, with extensive documentation on its functional properties.
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