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Recombinant Mouse Fgf1 Protein, His-tagged

Cat.No. : Fgf1-7205M
Product Overview : Recombinant Mouse Fgf1 protein with a His tag was expressed in E. coli.
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  • Gene Information
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Description : Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrin ITGAV:ITGB3. Its binding to integrin, subsequent ternary complex formation with integrin and FGFR1, and the recruitment of PTPN11 to the complex are essential for FGF1 signaling. Induces the phosphorylation and activation of FGFR1, FRS2, MAPK3/ERK1, MAPK1/ERK2 and AKT1. Can induce angiogenesis.
Source : E. coli
Species : Mouse
Tag : His
Form : Liquid
Protein length : 16-155
AA Sequence : MGSSHHHHHHSSGLVPRGSHMFNLP LGNYKKPKLLYCSNGGHFLRILPDG TVDGTRDRSDQHIQLQLSAESAGEV YIKGTETGQYLAMDTEGLLYGSQTP NEECLFLERLEENHYNTYTSKKHAE KNWFVGLKKNGSCKRGPRTHYGQKA ILFLPLPVSSD
Endotoxin : < 1.0 EU/μg of protein (determined by LAL method)
Purity : > 90 %
Stability : Shelf life: one year from despatch.
Storage : Store undiluted at 2-8 centigrade for up to two weeks or (in aliquots) at -20 or -70 centigrade for longer.
Avoid repeated freezing and thawing.
Concentration : 1.0 mg/mL (determined by Bradford assay)
Storage Buffer : 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT, 30 % glycerol, 0.1 M NaCl
Gene Name : Fgf1 fibroblast growth factor 1 [ Mus musculus (house mouse) ]
Official Symbol : Fgf1
Synonyms : Fgf1; fibroblast growth factor 1; Fam; Fgf; Fgfa; Dffrx; Fgf-1; Fgf2b; fibroblast growth factor 1; HBGF-1; aFGF; acidic fibroblast growth factor; fibroblast growth factor 1 (acidic); fibroblast growth factor 2b; heparin-binding growth factor 1
Gene ID : 14164
mRNA Refseq : NM_010197
Protein Refseq : NP_034327
UniProt ID : P61148

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any clinical trials using FGF1 for heart disease? 06/28/2020

Yes, there have been clinical trials exploring the use of FGF1 in treating heart disease, specifically in promoting cardiac angiogenesis.

Can FGF1 be used in regenerative medicine? 09/15/2018

Yes, FGF1 is being investigated for its potential in regenerative medicine to repair damaged tissues and organs.

Can FGF1 be used in the treatment of diabetes? 03/29/2018

FGF1 has shown potential in improving insulin sensitivity and glucose regulation in preclinical studies, but further research is needed for clinical applications.

What safety concerns are associated with FGF1 use? 01/15/2017

Safety concerns include the risk of uncontrolled cell growth, which could lead to cancer, and the need for precise dosing and administration.

Are there any side effects associated with FGF1 therapy? 12/10/2016

Potential side effects may include inflammation at the application site, allergic reactions, and adverse effects related to uncontrolled cell growth.

Customer Reviews (3)

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Reviews
08/06/2021

    By using FGF1 protein, I can explore the mechanisms underlying cell division, cell cycle control, and the molecular pathways associated with these processes.

    06/03/2021

      The protein's interaction with other APC/C subunits enables the study of its function and the investigation of its involvement in various cellular processes.

      11/25/2018

        As a researcher utilizing FGF1 protein in my trials, I can highlight its advantages and the valuable support provided by the manufacturer in facilitating my research.

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