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Recombinant Mouse Ilk Protein, Myc/DDK-tagged

Cat.No. : Ilk-3525M
Product Overview : Purified recombinant protein of mouse full-length integrin linked kinase (Ilk), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 51.4 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Ilk integrin linked kinase [ Mus musculus (house mouse) ]
Official Symbol : Ilk
Synonyms : ILK; integrin linked kinase; integrin-linked protein kinase; integrin binding protein kinase; ESTM24; AA511515
Gene ID : 16202
mRNA Refseq : NM_010562
Protein Refseq : NP_034692
UniProt ID : O55222

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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In what diseases might ILK play an important role? 12/21/2019

ILK may play an important role, in a variety of diseases such as cancer, cardiovascular disease, inflammatory disease. Specific research is still in progress.

Which signaling pathways are involved in ILK? 09/23/2019

The interacts with multiple signaling pathways, including PI3K/AKT, Wnt/β-catenin, Hippo and NF-κB, and regulates cell function and behavior.

What is the function of ILK in the cell? 05/24/2019

It is a kind of protein kinases, involved in cell adhesion, movement, proliferation and survival, and many other biological processes.

What role does ILK play in tumor development? 01/13/2019

This protein is associated with tumor cell proliferation, tumor angiogenesis, invasion and metastasis in tumors, and may play a role in promoting tumor development.

Does ILK play a role in organ development and regeneration? 01/02/2019

ILK may play an important regulatory role in organ development and regeneration, involving in cell proliferation, differentiation and maintenance of tissue structure.

What are the prospects for the cellular signaling mechanism and therapeutic potential of ILK? 01/02/2019

For the cellular signaling mechanism of ILK, further in-depth studies are needed to clarify its specific role. In the treatment of potential, hope to be able to from the relevant regulatory mechanism of ILK, explore new targeted therapeutic strategies.

Customer Reviews (3)

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Reviews
08/25/2020

    Easy to operate, cost-effective.

    01/24/2020

      It has high sensitivity and strong specificity.

      10/26/2019

        High catalytic efficiency, short time, saving time.

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