Recombinant Mouse Ilk Protein, Myc/DDK-tagged
Cat.No. : | Ilk-3525M |
Product Overview : | Purified recombinant protein of mouse full-length integrin linked kinase (Ilk), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
- Related Products
Description : | Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 51.4 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Ilk integrin linked kinase [ Mus musculus (house mouse) ] |
Official Symbol : | Ilk |
Synonyms : | ILK; integrin linked kinase; integrin-linked protein kinase; integrin binding protein kinase; ESTM24; AA511515 |
Gene ID : | 16202 |
mRNA Refseq : | NM_010562 |
Protein Refseq : | NP_034692 |
UniProt ID : | O55222 |
Products Types
◆ Recombinant Protein | ||
ILK-5158H | Recombinant Human ILK Protein, GST-tagged | +Inquiry |
ILK-4525M | Recombinant Mouse ILK Protein, His (Fc)-Avi-tagged | +Inquiry |
ILK-1179H | Recombinant Human ILK Protein (1-228 aa), His-tagged | +Inquiry |
ILK-2708R | Recombinant Rat ILK Protein, His (Fc)-Avi-tagged | +Inquiry |
ILK-2080R | Recombinant Rhesus Macaque ILK Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
ILK-5219HCL | Recombinant Human ILK 293 Cell Lysate | +Inquiry |
ILK-5220HCL | Recombinant Human ILK 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (6)
Ask a questionILK may play an important role, in a variety of diseases such as cancer, cardiovascular disease, inflammatory disease. Specific research is still in progress.
The interacts with multiple signaling pathways, including PI3K/AKT, Wnt/β-catenin, Hippo and NF-κB, and regulates cell function and behavior.
It is a kind of protein kinases, involved in cell adhesion, movement, proliferation and survival, and many other biological processes.
This protein is associated with tumor cell proliferation, tumor angiogenesis, invasion and metastasis in tumors, and may play a role in promoting tumor development.
ILK may play an important regulatory role in organ development and regeneration, involving in cell proliferation, differentiation and maintenance of tissue structure.
For the cellular signaling mechanism of ILK, further in-depth studies are needed to clarify its specific role. In the treatment of potential, hope to be able to from the relevant regulatory mechanism of ILK, explore new targeted therapeutic strategies.
Customer Reviews (3)
Write a reviewEasy to operate, cost-effective.
It has high sensitivity and strong specificity.
High catalytic efficiency, short time, saving time.
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