Recombinant Mouse Pde4a Protein, Myc/DDK-tagged

• Cat.No.: Pde4a-4745M
• Product Overview: Purified recombinant protein of mouse full-length phosphodiesterase 4A, cAMP specific (Pde4a), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 93.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Pde4a phosphodiesterase 4A, cAMP specific [ Mus musculus (house mouse) ]
• Official Symbol: Pde4a
• Synonyms: PDE4A; phosphodiesterase 4A, cAMP specific; cAMP-specific 3,5-cyclic phosphodiesterase 4A; dunce; cAMP-specific phosphodiesterase PDE4A; cyclic AMP specific phosphodiesterase PDE4A5A; Dpde2; D9Ertd60e
• Gene ID: 18577
• mRNA Refseq: NM_183408
• Protein Refseq: NP_899668
• UniProt ID: O89084

Reviews

12/05/2022

PDE4A requires less storage environment.

07/26/2022

The expression of PDE4A was stable.

02/08/2022

It has the advantage of easy operation in the expression system and can improve the expression efficiency.

Q&As

How effective are PDE4A inhibitors in the treatment of asthma?

The inhibitors have been used in the treatment of asthma, and studies have shown that they can significantly reduce the number of asthma attacks and the use of drug D.

How to introduce the structure of PDE4A?

This protein has multiple conserved regions and different subtypes, which is of great significance for the selective inhibition of drugs.

What is a selective PDE4A inhibitor?

Selective PDE4A inhibitors refer to drug molecules that target only the PDE4A protein and do not inhibit other PDE4 homologs.

What is the mechanism by which PDE4A regulates T cell-mediated autoimmune responses?

It plays an important role in the activation and regulation of T cells by regulating cAMP levels, and is involved in T cell-mediated autoimmune responses.

Are levels of PDE4A associated with sleep disturbances?

Studies have shown that PDE4A depletion may be related to sleep-wake behavior and time stress response, but its specific role needs to be further studied.

What is the expression pattern of PDE4A in T cells?

In T cells, PDE4A is mainly expressed in the cytoplasm and peripheral regions of the nuclear membrane.