Recombinant Mouse TNFSF12 Protein (Arg105-His249), RlgG Fc-tagged

• Cat.No.: TNFSF12-810M
• Product Overview: Recombinant Mouse TNFSF12 Protein (NP_035744.1) (Arg105-His249) was produced by HEK293 Cells expression system. This protein was expressed with the Fc region of rabbit IgG at the N-terminus.

Specification

• Description: TNFSF12 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is a ligand for the FN14/TWEAKR receptor. TNFSF12 has overlapping signaling functions with TNF, but displays a much wider tissue distribution. It can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. It is also found that TNFSF12 promotes proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. TNFSF12 also is a weak inducer of apoptosis in some cell types and mediates NF-kappa-B activation.
• Source: HEK293
• Species: Mouse
• Tag: RlgG Fc
• Predicted N Terminal: Ser
• Form: Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
• Molecular Mass: The recombinant mouse TNFSF12 consists of 396 amino acids and predicts a molecular mass of 43.5 kDa.
• Protein length: Arg105-His249
• Endotoxin: < 1.0 EU per μg protein as determined by the LAL method.
• Purity: > 95 ％ as determined by SDS-PAGE.
• Stability: Samples are stable for up to twelve months from date of receipt at -70 centigrade.
• Storage: Store it under sterile conditions at -20 centigrade to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 mg/ml. Centrifuge the vial at 4℃ before opening to recover the entire contents.
• Shipping: In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature.
  Bulk packages of recombinant proteins are provided as frozen liquid. They are shipped out with blue ice unless customers require otherwise.

Gene Information

• Gene Name: Tnfsf12 tumor necrosis factor (ligand) superfamily, member 12 [ Mus musculus ]
• Official Symbol: TNFSF12
• Synonyms: TNFSF12; Dr3l; Apo3l; Dr3lg; Tweak
• Gene ID: 21944
• mRNA Refseq: NM_011614
• Protein Refseq: NP_035744
• UniProt ID: O54907