| Description : |
IL17, also known as IL17a, is a cytokine belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological pr centigradeesses including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (mon centigradeytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are ass centigradeiated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. |
| Source : |
E. coli |
| Species : |
Rabbit |
| Tag : |
His |
| Predicted N Terminal : |
Met |
| Form : |
Lyophilized from sterile PBS, pH, 7.4. Normally 5 %- 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. |
| Bio-activity : |
Measured by its binding ability in a functional ELISA. Immobilized rabbit IL17a at 10μg/mL (100μL/well) can bind rat IL17RA-Fc3, the EC50 of rat IL17RA-Fc3 is 1-30 ng/mL. |
| Molecular Mass : |
The recombinant rabbit IL17A consists of 131 amino acids and predicts a molecular mass of 15.1 kDa |
| Protein length : |
Gly24-Ala153 |
| Endotoxin : |
< 1.0 EU per μg protein as determined by the LAL method. |
| Purity : |
> 95 % as determined by SDS-PAGE. |
| Storage : |
Samples are stable for up to twelve months from date of receipt at-70 centigrade. Store it under sterile conditions at-20 centigrade to-80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Reconstitution : |
It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
| Official Symbol : |
IL17A |
| Synonyms : |
IL17A;interleukin 17A;interleukin-17A |
