Recombinant Rat Il23r Protein, His-tagged

• Cat.No.: Il23r-1030R
• Product Overview: Recombinant Rat Il23r Protein (Ile25-Leu355) with His tag was expressed in 293F.

Specification

• Description: Predicted to enable cytokine binding activity and cytokine receptor activity. Predicted to contribute to interleukin-12 receptor binding activity; interleukin-23 binding activity; and interleukin-23 receptor activity. Predicted to be involved in several processes, including positive regulation of defense response to virus by host; regulation of cytokine production; and response to interferon-gamma. Predicted to be part of interleukin-23 receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); inflammatory bowel disease (multiple); pulmonary hypertension; rhinitis; and systemic scleroderma. Orthologous to human IL23R (interleukin 23 receptor).
• Source: HEK293F
• Species: Rat
• Tag: His
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 65.2 kDa; Accurate Molecular Mass: 110 kDa
• Protein length: Ile25-Leu355
• Purity: > 97%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Gene Information

• Gene Name: Il23r interleukin 23 receptor [ Rattus norvegicus (Norway rat) ]
• Official Symbol: Il23r
• Synonyms: IL23R; interleukin 23 receptor
• Gene ID: 689932
• mRNA Refseq: XM_039108697
• Protein Refseq: XP_038964625
• UniProt ID: F1LX96

Reviews

10/21/2020

High specificity in ELISA.

04/28/2016

Effective in autoimmune models.

03/30/2016

Suitable for receptor binding studies.

Q&As

How does IL23R activation affect T-cell differentiation?

IL23R activation promotes Th17 cell differentiation.

Does IL23R have alternative splicing variants?

IL23R has multiple alternative splicing variants.

Does IL23R have any post-translational modifications that affect its stability?

IL23R undergoes phosphorylation that affects its stability.

What is the half-life of IL23R protein in activated T-cells?

The half-life of IL23R protein in activated T-cells is approximately 48 hours.

Are there any microRNAs that regulate IL23R expression?

MicroRNAs like miR-20a regulate IL23R expression.

How does IL23R contribute to cytokine release?

IL23R contributes to the release of pro-inflammatory cytokines like IL-17.

What role does IL23R play in autoimmune diseases?

IL23R is implicated in autoimmune diseases like Crohn's.

How does IL23R expression change during infection?

IL23R expression is upregulated during bacterial infection.

Does IL23R form homodimers or heterodimers?

IL23R forms heterodimers with IL-12Rβ1.

What intracellular pathways are activated by IL23R?

IL23R activates the JAK-STAT and NF-κB pathways.