This gene encodes a member of the immunoglobulin superfamily. The encoded protein contains a single immunoglobulin (Ig) domain and is a receptor that relays inhibitory signals to suppress the immune response. Alternative splicing results in multiple transcript variants. Polymorphisms in this gene have been associated with an increased risk of rheumatoid arthritis.
Synonyms
BTLA; B and T lymphocyte associated; B- and T-lymphocyte attenuator; BTLA1; CD272; B and T lymphocyte attenuator; B- and T-lymphocyte-associated protein; FLJ16065; MGC129743;
BTLA involved in several pathways and played different roles in them. We selected most pathways BTLA participated on our site, such as Adaptive Immune System, Costimulation by the CD28 family, Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with BTLA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
BTLA has several biochemical functions, for example, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by BTLA itself. We selected most functions BTLA had, and list some proteins which have the same functions with BTLA. You can find most of the proteins on our site.
BTLA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BTLA here. Most of them are supplied by our site. Hope this information will be useful for your research of BTLA.
TNFRSF14; PTPN6; PTPN11
Venner, JM; Famulski, KS; et al. Molecular Landscape of T Cell-Mediated Rejection in Human Kidney Transplants: Prominence of CTLA4 and PD Ligands. AMERICAN JOURNAL OF TRANSPLANTATION 14:2565-2576(2014).
Uchiyama, M; Jin, X; et al. Combination of Anti-BTLA Antibody (6B2) and Anti-PD-1 Antibody (PIM-2) Induced Indefinite Survival of Fully MHC-Mismatched Murine Cardiac Allograft.. TRANSPLANTATION 98:311-311(2014).
