il6st
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  • Official Full Name
  • Interleukin 6 signal transducer (gp130, oncostatin M receptor)
  • Background
  • Glycoprotein 130 (also known as gp130, IL6ST, IL6-beta or CD130) is a transmembrane protein which is the founding member of the class of all cytokine receptors. It forms one subunit of type I cytokine receptors within the IL-6 receptor family. It is often referred to as the common gp130 subunit, and is important for signal transduction following cytokine engagement. As with other type I cytokine receptors, gp130 possesses a WSXWS amino acid motif that ensures correct protein folding and ligand binding. It interacts with Janus kinases to elicit an intracellular signal following receptor interaction with its ligand. Structurally, gp130 is composed of five fibronectin type-III domains and one immunoglobulin-like C2-type (immunoglobulin-like) domain in its extracellular portion.
  • Synonyms
  • IL6ST; CD130; CDW130; GP130; IL-6RB; Interleukin 6 signal transducer (gp130, oncostatin M receptor)
Cat.#:IL6ST-353MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse IL6ST Protein, Fc-tagged
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Cat.#:IL6ST-5171HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human IL6ST Protein, GST-tagged
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Cat.#:IL6ST-1622HTag:FC/His
Source (Host):NS0Species:Human
Product nameRecombinant Human IL6ST, Fc-His
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Cat.#:IL6ST-1682HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human IL6ST
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Cat.#:IL6ST-26366THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human IL6ST
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Cat.#:IL6ST-265HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL6ST Protein, Fc-tagged
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Cat.#:IL6ST-271HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL6ST, ENLYFQ tagged
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Cat.#:IL6ST-787HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL6ST protein, His-tagged
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Cat.#:IL6ST-788HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human IL6ST protein, His-tagged
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Cat.#:Il6st-173MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Il6st, His-tagged
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Cat.#:Il6st-1743MTag:Fc
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Interleukin 6 Signal Transducer, Fc-His
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Cat.#:Il6st-2208MTag:FC/His
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Il6st, Fc-His tagged
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Cat.#:Il6st-222MTag:His/S
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il6st protein, His/S-tagged
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Cat.#:Il6st-356MTag:His
Source (Host):Insect cellSpecies:Mouse
Product nameRecombinant Mouse Il6st Protein, His-tagged
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Cat.#:Il6st-4011MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Il6st, His tagged
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Cat.#:Il6st-6964MTag:FC/His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Il6st, Fc-His tagged
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Cat.#:Il6st-789MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Il6st protein, His & T7-tagged
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Cat.#:Il6st-4091RTag:FC/His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Il6st, Fc-His tagged
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Cat.#:Il6st-4092RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Il6st, His tagged
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Cat.#:Il6st-539RTag:Fc Chimera
Source (Host):NSO cellsSpecies:Rat
Product nameRecombinant Rat Il6st, Fc Chimera
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Cat.#:Il6st-790RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Il6st protein, His & GST-tagged
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Cat.#:IL6ST-2255RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey IL6ST Protein, His-tagged
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Cat.#:IL6ST-6434CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken IL6ST
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Cat.#:IL6ST-6303ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish IL6ST
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Cat.#:IL6ST-935HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human IL6ST cell lysate
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Cat.#:IL6ST-001MCLTag:
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse IL6ST cell lysate
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Cat.#:IL6ST-1882RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat IL6ST cell lysate
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Cat.#:IL6ST-946CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus IL6ST cell lysate
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Involved Pathway

IL6ST involved in several pathways and played different roles in them. We selected most pathways IL6ST participated on our site, such as Cytokine-cytokine receptor interaction, Signaling pathways regulating pluripotency of stem cells, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL6ST were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
IL12RB2; IL13; IFNAR1; Ccl12; CCR1L1; IFNA8; CRFB16; GHRA; CCL8; LEPB
Signaling pathways regulating pluripotency of stem cells
NRAS; ACVR2B; MAP2K2; PAX6; PCGF2; SMAD4; WNT8A; HAND1; INHBA; PIK3CG
Jak-STAT signaling pathway
IFNGR1; IFNE; IL12BA; CTF1; IL12A; IFNA6; STAT1A; CCND2A; LIF; MCL1A
Viral carcinogenesis
SCIN; HLA-C; HLA-G; HIST1H2BD; GTF2H1; EGR3; RBL2; CCNA1; CREB5; HIST1H2BG

Protein Function

IL6ST has several biochemical functions, for example, ciliary neurotrophic factor receptor activity, ciliary neurotrophic factor receptor binding, growth factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL6ST itself. We selected most functions IL6ST had, and list some proteins which have the same functions with IL6ST. You can find most of the proteins on our site.
Function
Related Protein
Function ciliary neurotrophic factor receptor activity
Related Protein IL6ST
Function ciliary neurotrophic factor receptor binding
Related Protein CLCF1; IL6ST; CNTF; LIFR; Ctf2
Function growth factor binding
Related Protein LTBP4; HTRA1B; ERBB3; LIFR; SDCBP; TEK; ACVR2A; NKD2; REG3B; RHBDF1
Function contributes_to growth factor binding
Related Protein ACVR1B; IL6ST; TGFBR1; ERBB2
Function interleukin-11 binding
Related Protein IL6ST
Function interleukin-11 receptor activity
Related Protein IL6ST
Function interleukin-27 receptor activity
Related Protein IL27RA; IL6ST
Function contributes_to interleukin-6 binding
Related Protein IL6ST
Function contributes_to interleukin-6 receptor activity
Related Protein IL6R; Il6ra; IL6ST
Function contributes_to interleukin-6 receptor binding
Related Protein IL6R; Il6ra; IL6; IL6ST
Function contributes_to leukemia inhibitory factor receptor activity
Related Protein LIFR; IL6ST
Function contributes_to oncostatin-M receptor activity
Related Protein IL6ST; OSMR; LIFR
Function protein binding
Related Protein USH2A; GEMIN8; CCDC60; GRIA2; CIAPIN1; KIF20B; MMS19; PSMD14; PRAME; NSMCE2
Function protein homodimerization activity
Related Protein CCBL1; NTRK2; GPD1; DROSHA; ATPIF1B; PRMT8; HOMER2; SDCBP2; SMAD1; TREX1

Interacting Protein

IL6ST has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL6ST here. Most of them are supplied by our site. Hope this information will be useful for your research of IL6ST.
Stat3; LIF; K2; STAT1; OSM; CNTF; vIL-6; ptpn11-cerae-protein; IL6

IL6ST Related Gene Family

IL