OSM

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OSM

Official Full Name oncostatin M
Background Oncostatin M, also known as OSM, is a protein that in humans is encoded by the OSM gene. OSM is a pleiotropic cytokine that belongs to the interleukin 6 group of cytokines. Of these cytokines it most closely resembles leukemia inhibitory factor (LIF) in both structure and function. However, it is as yet poorly defined and is proving important in liver development, haematopoeisis, inflammation and possibly CNS development. It is also associated with bone formation and destruction.
Synonyms OSM; oncostatin M; MGC20461; oncostatin-M; OTTHUMP00000198700
    • Species :
    • Bovine
    • Canine
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Swine
    • Source :
    • E.coli
    • HEK293
    • HEK293F
    • Human
    • Human Cell
    • Mammalian Cell
    • NSO
    • Yeast
    • Tag :
    • Fc
    • His
    • GST
    • N/A
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human OSM-130H Human Oncostatin M (rDNA derived) Reference standard N/A
    Human OSM-131H Recombinant Human Oncostatin M HEK293 N/A
    Human OSM-1472H Recombinant Human OSM, His-tagged E.coli His
    Human OSM-1766HCL Recombinant Human OSM cell lysate Human Cell N/A
    Human OSM-206H Recombinant Human OSM, His-tagged E.coli His
    Human OSM-259H Recombinant Human OSM, StrepII-tagged Human Cell Strep II
    Human OSM-25H Recombinant Human OSM protein E.coli N/A
    Human OSM-346H Recombinant Human Oncostatin M, His-tagged Human His
    Human OSM-358H Recombinant Human Oncostatin M Human N/A
    Human OSM-4374H Recombinant Human OSM Protein Yeast N/A
    Human OSM-463H Recombinant Human OSM protein, His-tagged HEK293F His
    Human OSM-513H Recombinant Human OSM protein HEK293
    Human OSM-514H Recombinant Human OSM protein HEK293 N/A
    Human OSM-656H Recombinant Human OSM, His-tagged, Biotinylated Human Cell His
    Human OSM-657H Recombinant Human OSM, Fc-tagged, Biotinylated Human Cell Fc
    Human OSM-658H Recombinant Human OSM, Fc-tagged Human Cell Fc
    Human OSM-6998H Recombinant Human OSM, His tagged Human Cell His
    Human OSM-759H Recombinant Human OSM protein, His & GST-tagged E.coli His/GST
    Human OSM-962H Recombinant Human OSM protein E.coli N/A
    Human OSM-963H Recombinant Human OSM protein E.coli N/A
    Human OSM-964H Recombinant Human OSM Protein E.coli N/A
    Mouse OSM-1659MCL Recombinant Mouse OSM cell lysate Human Cell N/A
    Mouse Osm-1771M Recombinant Mouse Oncostatin M NSO N/A
    Mouse Osm-4358M Recombinant Mouse Osm Protein Yeast N/A
    Mouse Osm-524M Recombinant Mouse Osm protein E.coli N/A
    Mouse Osm-760M Recombinant Mouse Osm protein, His-tagged E.coli His
    Mouse Osm-8302M Recombinant Mouse Osm E.coli N/A
    Mouse Osm-841M Recombinant Mouse Osm Protein, His-tagged HEK293 His
    Rat OSM-4208R Recombinant Rat OSM Protein Mammalian Cell His
    Rat Osm-585R Recombinant Rat Osm protein E.coli N/A
    Rhesus Macaque OSM-3255R Recombinant Rhesus monkey OSM Protein, His-tagged Mammalian Cell His
    Canine OSM-4338C Recombinant Canine OSM Protein Yeast N/A
    Bovine OSM-4337B Recombinant Bovine OSM Protein Yeast N/A
    Swine OSM-4391S Recombinant Swine OSM Protein Yeast N/A

    OSM involved in several pathways and played different roles in them. We selected most pathways OSM participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with OSM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction IL-15RA; TNFRSF8; TGFB1A; CCL13; CCR6; IL8L2; FIGF; Il2; GM13305; IFNA21
    PIK-Akt signaling pathway RHEB; ITGA5; GNG4; PPP2CB; GNB2; FLT4; PPP2R5B; CREB3L3; BCL2L1; GNG7
    Jak-STAT signaling pathway BCL2A; IL4R; Il6ra; PIK3R2; GM-CSF; AOX2P; MCL1; LEPA; IFNA8; IFNA3

    OSM has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by OSM itself. We selected most functions OSM had, and list some proteins which have the same functions with OSM. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activity LIF; VSTM1; GM13288; INHBC; CMTM4; INHBAA; IL36B; OSTN; IL9; THPO
    growth factor activity FGF13; GDF2; CSF1; COL20A1; KLK1B4; FGF12; GDNFA; MDKB; PDGFB; OGN
    oncostatin-M receptor binding OSM

    OSM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OSM here. Most of them are supplied by our site. Hope this information will be useful for your research of OSM.

    IL6ST; LIFR; COL4A6; TNNT1

    Lapeire, L; Hendrix, A; et al. Cancer-Associated Adipose Tissue Promotes Breast Cancer Progression by Paracrine Oncostatin M and Jak/STAT3 Signaling. CANCER RESEARCH 74:6806-6819(2014).
    Torres, C; Perales, S; et al. Serum Cytokine Profile in Patients With Pancreatic Cancer. PANCREAS 43:1042-1049(2014).

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