OSM
-
Official Full Name
oncostatin M
-
Overview
Oncostatin M, also known as OSM, is a protein that in humans is encoded by the OSM gene. OSM is a pleiotropic cytokine that belongs to the interleukin 6 group of cytokines. Of these cytokines it most closely resembles leukemia inhibitory factor (LIF) in both structure and function. However, it is as yet poorly defined and is proving important in liver development, haematopoeisis, inflammation and possibly CNS development. It is also associated with bone formation and destruction. -
Synonyms
OSM; oncostatin M; MGC20461; oncostatin-M; OTTHUMP00000198700;
- Recombinant Proteins
- Cell & Tissue Lysates
- GMP Proteins
- Protein Pre-coupled Magnetic Beads
- Transfected Stable Cell Lines
- Bovine
- Canine
- Human
- Mouse
- Rat
- Rhesus macaque
- Rhesus Macaque
- Swine
- E.coli
- HEK293
- HEK293F
- HEK293T
- Human
- Human Cell
- Human cells
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Yeast
- C
- His
- Fc
- Flag
- GST
- His (Fc)
- Avi
- Myc
- His|GST
- DDK
- N/A
- N
- Strep II
- Tag Free
- Involved Pathway
- Protein Function
- Interacting Protein
- OSM Related Articles
- OSM Related Research Area
OSM involved in several pathways and played different roles in them. We selected most pathways OSM participated on our site, such as Cytokine-cytokine receptor interaction, PIK-Akt signaling pathway, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with OSM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Cytokine-cytokine receptor interaction | CCL21B;GM1987;CCL19;IL17RB;IL7;INHBE;TNFSF9;GM10591;GM13305 |
PIK-Akt signaling pathway | IL2RA;EIF4E2;IFNA12;IFNA7;PIK3CA;PIK3CD;ITGB5;CASP9;PCK1 |
Jak-STAT signaling pathway | FHL1;IL21R;THPO;CSH2;IL21R.1;SOCS3B;IL4R;IFNPHI1;GM2002 |
OSM has several biochemical functions, for example, cytokine activity, growth factor activity, oncostatin-M receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by OSM itself. We selected most functions OSM had, and list some proteins which have the same functions with OSM. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
cytokine activity | IL17F;IL17A/F3;TNFSF4;HMGB1;IL5;Il23a; Il12b;IL18;GDF11;Ccl12 |
growth factor activity | INHBA;KLK1B3;VEGFA;NTF4;PDGFAA;FGF18B;HBEGF;BMP8A;NRG4 |
oncostatin-M receptor binding |
OSM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OSM here. Most of them are supplied by our site. Hope this information will be useful for your research of OSM.
IL6ST; LIFR; COL4A6; TNNT1
- Q&As
- Reviews
Q&As (7)
Ask a questionOSM can influence cancer progression by altering the tumor microenvironment and affecting tumor cell behavior.
OSM plays a key role in regulating inflammatory and immune responses, modulating cytokine production and immune cell activity.
OSM aids in wound healing and tissue regeneration, promoting cell growth and repair mechanisms.
OSM is implicated in autoimmune diseases, contributing to inflammation and joint damage in conditions like rheumatoid arthritis.
OSM is involved in liver fibrosis, impacting the development and progression of hepatic diseases.
OSM regulates cellular processes like growth, differentiation, and apoptosis, affecting various tissue functions.
Changes in OSM signaling can impact cardiovascular health, influencing disease development and progression.
Customer Reviews (3)
Write a reviewOutstanding protein-protein interaction studies, vital for our projects.
High-quality protein characterization, fundamental for our experiments.
Expertise in peptide synthesis, accelerates our peptide-based research.
Ask a Question for All OSM Products
Required fields are marked with *
My Review for All OSM Products
Required fields are marked with *