osm
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  • Official Full Name
  • oncostatin M
  • Background
  • Oncostatin M, also known as OSM, is a protein that in humans is encoded by the OSM gene. OSM is a pleiotropic cytokine that belongs to the interleukin 6 group of cytokines. Of these cytokines it most closely resembles leukemia inhibitory factor (LIF) in both structure and function. However, it is as yet poorly defined and is proving important in liver development, haematopoeisis, inflammation and possibly CNS development. It is also associated with bone formation and destruction.
  • Synonyms
  • OSM; oncostatin M; MGC20461; oncostatin-M; OTTHUMP00000198700
Cat.#:OSM-4374HTag:
Source (Host):YeastSpecies:Human
Product nameRecombinant Human OSM Protein
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Cat.#:Osm-4358MTag:
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse Osm Protein
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Cat.#:OSM-4338CTag:
Source (Host):YeastSpecies:Canine
Product nameRecombinant Canine OSM Protein
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Cat.#:OSM-4337BTag:
Source (Host):YeastSpecies:Bovine
Product nameRecombinant Bovine OSM Protein
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Cat.#:OSM-4391STag:
Source (Host):YeastSpecies:Swine
Product nameRecombinant Swine OSM Protein
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Cat.#:OSM-131HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human Oncostatin M
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Cat.#:OSM-25HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Oncostatin M
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Cat.#:Osm-1771MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Oncostatin M
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Cat.#:OSM-206HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human OSM, His-tagged
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Cat.#:OSM-1472HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human OSM, His-tagged
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Cat.#:OSM-259HTag:Strep II
Source (Host):HEK293Species:Human
Product nameRecombinant Human OSM, StrepII-tagged
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Cat.#:OSM-463HTag:His
Source (Host):HEK293FSpecies:Human
Product nameRecombinant Human OSM protein, His-tagged
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Cat.#:OSM-513HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human OSM
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Cat.#:OSM-514HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human OSM protein
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Cat.#:OSM-656HTag:His
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human OSM, His-tagged, Biotinylated
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Cat.#:OSM-657HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human OSM, Fc-tagged, Biotinylated
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Cat.#:OSM-658HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human OSM, Fc-tagged
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Cat.#:OSM-6998HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human OSM, His tagged
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Cat.#:OSM-759HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human OSM protein, His & GST-tagged
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Cat.#:OSM-962HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human OSM Protein
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Cat.#:OSM-963HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human OSM Protein
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Cat.#:OSM-964HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human OSM Protein
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Cat.#:Osm-524MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Osm
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Cat.#:Osm-760MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Osm protein, His-tagged
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Cat.#:Osm-8302MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Osm
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Cat.#:Osm-841MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Osm Protein, His-tagged
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Cat.#:OSM-4208RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat OSM Protein
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Cat.#:Osm-585RTag:
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Osm
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Cat.#:OSM-3255RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey OSM Protein, His-tagged
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Cat.#:OSM-346HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Oncostatin M, His-tagged
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Cat.#:OSM-358HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Oncostatin M
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Cat.#:OSM-1766HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human OSM cell lysate
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Cat.#:OSM-1659MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse OSM cell lysate
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Cat.#:OSM-130HTag:
Source (Host):Species:Human
Product nameHuman Oncostatin M (rDNA derived) Reference standard
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Involved Pathway

OSM involved in several pathways and played different roles in them. We selected most pathways OSM participated on our site, such as Cytokine-cytokine receptor interaction, PIK-Akt signaling pathway, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with OSM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
PRP2; CX3CR1; FLT3LG; IL12B; TNFRSF12A; KITB; IFNG; TNFRSF9; PF4; LEPR
PIK-Akt signaling pathway
PPP2CB; PDGFA; PPP2R2C; COL27A1; INSR; RELA; PPP2R2D; MAP2K2; GRB2; RBL2
Jak-STAT signaling pathway
MCL1; IL21R.1; LIFRA; LEPA; FHL1; CCND2; RNF207B; IL12RB2; STAT2; TYK2

Protein Function

OSM has several biochemical functions, for example, cytokine activity, growth factor activity, oncostatin-M receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by OSM itself. We selected most functions OSM had, and list some proteins which have the same functions with OSM. You can find most of the proteins on our site.
Function
Related Protein
Function cytokine activity
Related Protein Il1f8; FAM3B; BMP15; GDF9; BMP3; TNFRSF11B; GDF11; CCL19A.1; CSF1B; GREM1A
Function growth factor activity
Related Protein FGF3; IL11; EFEMP1; GPI1; FGF18A; FGF10; NENF; PPBP; IL7; BMP8B
Function oncostatin-M receptor binding
Related Protein OSM

Interacting Protein

OSM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with OSM here. Most of them are supplied by our site. Hope this information will be useful for your research of OSM.
IL6ST; LIFR; COL4A6; TNNT1

OSM Related Articles

Lapeire, L; Hendrix, A; et al. Cancer-Associated Adipose Tissue Promotes Breast Cancer Progression by Paracrine Oncostatin M and Jak/STAT3 Signaling. CANCER RESEARCH 74:6806-6819(2014).
Torres, C; Perales, S; et al. Serum Cytokine Profile in Patients With Pancreatic Cancer. PANCREAS 43:1042-1049(2014).