snca
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  • Official Full Name
  • synuclein, alpha (non A4 component of amyloid precursor)
  • Background
  • Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimers disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]
  • Synonyms
  • SNCA; synuclein, alpha (non A4 component of amyloid precursor); PD1; NACP; PARK1; PARK4; alpha-synuclein; synuclein alpha-140; non A-beta component of AD amyloid;
Cat.#:SNCA-2058HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human SNCA Protein, MYC/DDK-tagged
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Cat.#:Snca-1372RTag:GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Snca Protein, GST-tagged
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Cat.#:SNCA-76HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SNCA, A30P Mutant
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Cat.#:SNCA-234HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SNCA protein
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Cat.#:SNCA-235HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SNCA protein
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Cat.#:SNCA-237HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SNCA protein
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Cat.#:SNCA-240HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SNCA protein
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Cat.#:SNCA-245HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SNCA, His-tagged
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Cat.#:SNCA-27338THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SNCA, His-tagged
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Cat.#:SNCA-27343THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SNCA
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Cat.#:SNCA-27344THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SNCA
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Cat.#:SNCA-27348THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SNCA
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Cat.#:SNCA-2837HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SNCA, GST-tagged
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Cat.#:SNCA-290HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Synuclein, Alpha (Non A4 Component of Amyloid Precursor), A30P/A53T
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Cat.#:SNCA-291HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Synuclein, Alpha (Non A4 Component of Amyloid Precursor), Delta-NAC
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Cat.#:SNCA-292HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Synuclein, Alpha (Non A4 Component of Amyloid Precursor), 96-140
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Cat.#:SNCA-293HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Synuclein, Alpha (Non A4 Component of Amyloid Precursor), 1-60
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Cat.#:SNCA-294HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Synuclein, Alpha (Non A4 Component of Amyloid Precursor), E46K
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Cat.#:SNCA-295HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Synuclein, Alpha (Non A4 Component of Amyloid Precursor), 1-95
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Cat.#:SNCA-385HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SNCA Protein
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Cat.#:SNCA-5124HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Synuclein, Alpha (Non A4 Component Of Amyloid Precursor)
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Cat.#:SNCA-5125HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Synuclein, Alpha (Non A4 Component Of Amyloid Precursor)
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Cat.#:SNCA-5126HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Synuclein, Alpha (Non A4 Component Of Amyloid Precursor)
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Cat.#:SNCA-6937HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Synuclein, Alpha (non A4 component of amyloid precursor)
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Cat.#:SNCA-7034HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SNCA, None tagged
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Cat.#:SNCA-75HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SNCA, 112aa
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Cat.#:SNCA-77HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SNCA, A53T Mutant
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Cat.#:SNCA-78HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Synuclein, Alpha (Non A4 Component of Amyloid Precursor)
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Cat.#:SNCA-15673MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SNCA Protein
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Cat.#:Snca-2730MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Synuclein, Alpha
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Cat.#:Snca-386MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Snca Protein
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Cat.#:Snca-5826MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Snca protein, His-tagged
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Cat.#:Snca-387RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Snca Protein
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Cat.#:SNCA-5638RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SNCA Protein
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Cat.#:Snca-5827RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Snca protein, His-tagged
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Cat.#:SNCA-3389MTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) SNCA, His-tagged
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Cat.#:SNCA-6239CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SNCA
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Cat.#:SNCA-3390STag:His
Source (Host):Mammalian CellsSpecies:Pongo abelii (Sumatran orangutan)
Product nameRecombinant Sumatran orangutan SNCA, His-tagged
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Cat.#:SNCA-3391ATag:His
Source (Host):Mammalian CellsSpecies:Ateles geoffroyi (Black-handed spider monkey)
Product nameRecombinant Ateles geoffroyi (Black-handed spider monkey) SNCA, His-tagged
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Cat.#:SNCA-3392LTag:His
Source (Host):Mammalian CellsSpecies:Monkey
Product nameRecombinant Lagothrix lagotricha (Common woolly monkey) SNCA, His-tagged
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Cat.#:SNCA-3393ETag:His
Source (Host):Mammalian CellsSpecies:Erythrocebus patas (Red guenon) (Cercopithecus patas)
Product nameRecombinant Erythrocebus patas (Red guenon) (Cercopithecus patas) SNCA, His-tagged
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Cat.#:SNCA-3394PTag:His
Source (Host):Mammalian CellsSpecies:Pan paniscus (Pygmy chimpanzee) (Bonobo)
Product nameRecombinant Pan paniscus (Pygmy chimpanzee) (Bonobo) SNCA, His-tagged
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Cat.#:SNCA-3395STag:His
Source (Host):Mammalian CellsSpecies:Saguinus labiatus (Red-chested mustached tamarin)
Product nameRecombinant Saguinus labiatus (Red-chested mustached tamarin) SNCA, His-tagged
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Cat.#:SNCA-27339THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameNative Human SNCA
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Cat.#:SNCA-27341THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameNative Human SNCA
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Cat.#:SNCA-27342THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameNative Human SNCA
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Cat.#:SNCA-27345THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameNative Human SNCA
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Cat.#:SNCA-1634HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human SNCA 293 Cell Lysate
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Involved Pathway

SNCA involved in several pathways and played different roles in them. We selected most pathways SNCA participated on our site, such as Alzheimers disease, Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with SNCA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Alzheimers disease
ATP5C1; IDE; COX7A1; LPL; APH1C; NDUFAB1; COX7C; NDUFA10; BAD; CAPN1
Parkinsons disease
GNAI3; UQCRC2; TH; UBE2J1; ATP5G3; NDUFA1; GNAL; NDUFA6; SNCA; MT-ND4

Protein Function

SNCA has several biochemical functions, for example, alpha-tubulin binding, beta-tubulin binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SNCA itself. We selected most functions SNCA had, and list some proteins which have the same functions with SNCA. You can find most of the proteins on our site.
Function
Related Protein
Function alpha-tubulin binding
Related Protein ARL8A; FNTA; SLC6A2; BBS4; INO80; SERPINB1A; SPAST; ARL4C; WASH1; HDAC6
Function beta-tubulin binding
Related Protein PIFO; SIRT2; GABARAPL1; ARL8B; RACGAP1; LRPPRC; VAPB; UXT; PEX14; SNCA
Function calcium ion binding
Related Protein DGKA; CDH18A; KCNIP1B; PITPNM3; FKBP14; APCS; ACTN1; NECAB3; PADI6; CABP1
Function copper ion binding
Related Protein LOXL3; COMMD1; CCC2; MT3; SCO2; HIST2H3A; MOXD1L; SNCA; HEPHL1A; SLC11A2
Function cysteine-type endopeptidase inhibitor activity involved in apoptotic process
Related Protein BIRC5; NAIP1; RPS6KA3; PRDX5; CD27; LEF1; NOL3; SERPINB9; MT3; XIAP
Function dynein binding
Related Protein SERPINB1A; SNCA; WDR81; SMC3; PAFAH1B1A; DCTN6; WDR43; NEFH; KATNB1; BICD1
Function NOT fatty acid binding
Related Protein SERPINB1A; SNCA
Function ferrous iron binding
Related Protein SNCA; PLOD1; ISCA2; DNAJC24; TRR1; ALKBH2; SERPINB1A; UROD; ISCUB; CDO1
Function histone binding
Related Protein CD1D; PKN1; DAXX; SUPT6H; ATAD2; HIST1H4L; HIST1H4I; ASF1A; PRKCBB; CTSL1
Function identical protein binding
Related Protein IFI16; MID1; SID4; AGXT2L2; TK1; LECT2; TTR; SNCA; MUL1; BRAP
Function kinesin binding
Related Protein SYBU; JAKMIP1; DISC1; KIF18B; NUP62; KTN1; SERPINB1A; KCNC1; PRC1; IFT88
Function magnesium ion binding
Related Protein ADPRH; CDC42BPA; CLYBL; DUT; PRPSAP1; PPM1AA; ATP8B1; PKLR; CIB2; NLK
Function microtubule binding
Related Protein PRC1A; NUSAP1; CETN1; NDEL1; MTAP4; KIF18A; KIFC3; CEP350; KIF3B; DPYSL5
Function oxidoreductase activity
Related Protein CYP2AA6; CYP2X10.2; CYP2AD6; ADH8B; HEPHL1A; CYP26C1; CYP8B1; CYP51; CMAH; RDH10B
Function NOT phospholipase D inhibitor activity
Related Protein SERPINB1A; SNCA
Function phospholipase binding
Related Protein LMNB1; SELE; CALM3; CALM1; PTPN11; CALM2; Pla2r1; SERPINB1A; DGKQ; APOC2
Function phospholipid binding
Related Protein SDPR; PSD4; APOEB; ANXA5; MYOF; NBEA; NR5A1; APOA2; VAMP2; PLA2G2A
Function phosphoprotein binding
Related Protein MS4A2; TBL2; DPYSL3; FKBP4; GPRIN1; DPYS; URI1; CACNB2; MTOR; TBK1
Function protein N-terminus binding
Related Protein TRP53; ALG2; KCNIP2; ARF6; EIF3E; SCT; MAU2; VPS25; NPAT; FEZ1
Function protein binding
Related Protein Cd24a; FSHR; DDX58; Casp3; BNIPL; NAT9; TBC1D10A; MXD4; PES1; ZNF502
Function protein domain specific binding
Related Protein WNT5A; MITD1; YWHAG; HIST1H4I; CSNK2B; ERCC1; SP100; NF2; RAB27A; GABRR1
Function tau protein binding
Related Protein APOE; S100B; SERPINB1A; BIN1; PPP2R2A; FKBP4; DYRK1A; HDAC6; SNCA; AATF
Function transcription regulatory region DNA binding
Related Protein YY1; SALL3; IKZF3; ATF6B; KLF11; GABPB1; NR1D1; GATA4; SMARCA2; ZFP639
Function zinc ion binding
Related Protein ZDHHC18; MAN2C1; SHANK3; BTR22; TRIM5; PDLIM5B; RNF128A; PDLIM5; APOBEC2A; RARAB

SNCA Related Articles

Alvarez-Castelao, B; Gorostidi, A; et al. Epitope mapping of antibodies to alpha-synuclein in LRRK2 mutation carriers, idiopathic Parkinson disease patients, and healthy controls. FRONTIERS IN AGING NEUROSCIENCE 6:-(2014).
Daher, JPL; Volpicelli-Daley, LA; et al. Abrogation of alpha-synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:9289-9294(2014).