SNCA

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SNCA

Official Full Name synuclein, alpha (non A4 component of amyloid precursor)
Background Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimers disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq, Mar 2009]
Synonyms SNCA; synuclein, alpha (non A4 component of amyloid precursor); PD1; NACP; PARK1; PARK4; alpha-synuclein; synuclein alpha-140; non A-beta component of AD amyloid;
    • Species :
    • Ateles geoffroyi (Black-handed spider monkey)
    • Chicken
    • Cynomolgus monkey
    • Erythrocebus patas (Red guenon) (Cercopithecus patas)
    • Human
    • Monkey
    • Mouse
    • Pan paniscus (Pygmy chimpanzee) (Bonobo)
    • Pongo abelii (Sumatran orangutan)
    • Rat
    • Saguinus labiatus (Red-chested mustached tamarin)
    • Source :
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • HEK293T
    • Human
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • His-SUMO
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human SNCA-166H Recombinant Human SNCA protein, His-tagged E.coli His
    Human SNCA-5970H Recombinant Human SNCA Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Snca-5996M Recombinant Mouse Snca Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human SNCA-6456H Recombinant Human SNCA Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human SNCA-1634HCL Recombinant Human SNCA 293 Cell Lysate HEK293 N/A
    Human SNCA-2058H Recombinant Human SNCA Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human SNCA-234H Recombinant Human SNCA protein E.coli N/A
    Human SNCA-235H Recombinant Human SNCA protein E.coli N/A
    Human SNCA-237H Recombinant Human SNCA protein E.coli N/A
    Human SNCA-240H Recombinant Human SNCA protein E.coli N/A
    Human SNCA-245H Recombinant Human SNCA, His-tagged E.coli His
    Human SNCA-27338TH Recombinant Human SNCA, His-tagged E.coli His
    Human SNCA-27339TH Native Human SNCA E.coli N/A
    Human SNCA-27341TH Native Human SNCA E.coli N/A
    Human SNCA-27342TH Native Human SNCA E.coli N/A
    Human SNCA-27343TH Recombinant Human SNCA E.coli N/A
    Human SNCA-27344TH Recombinant Human SNCA E.coli N/A
    Human SNCA-27345TH Native Human SNCA E.coli N/A
    Human SNCA-27348TH Recombinant Human SNCA E.coli N/A
    Human SNCA-2837H Recombinant Human SNCA, GST-tagged E.coli GST
    Human SNCA-290H Recombinant Human Synuclein, Alpha (Non A4 Component of Amyloid Precursor), A30P/A53T E.coli N/A
    Human SNCA-291H Recombinant Human Synuclein, Alpha (Non A4 Component of Amyloid Precursor), Delta-NAC E.coli N/A
    Human SNCA-292H Recombinant Human Synuclein, Alpha (Non A4 Component of Amyloid Precursor), 96-140 E.coli N/A
    Human SNCA-293H Recombinant Human Synuclein, Alpha (Non A4 Component of Amyloid Precursor), 1-60 E.coli N/A
    Human SNCA-294H Recombinant Human Synuclein, Alpha (Non A4 Component of Amyloid Precursor), E46K E.coli N/A
    Human SNCA-295H Recombinant Human Synuclein, Alpha (Non A4 Component of Amyloid Precursor), 1-95 E.coli N/A
    Human SNCA-385H Recombinant Human SNCA Protein E.coli N/A
    Human SNCA-5124H Recombinant Human Synuclein, Alpha (Non A4 Component Of Amyloid Precursor) Human N/A
    Human SNCA-5125H Recombinant Human Synuclein, Alpha (Non A4 Component Of Amyloid Precursor) Human N/A
    Human SNCA-5126H Recombinant Human Synuclein, Alpha (Non A4 Component Of Amyloid Precursor) Human N/A
    Human SNCA-6937H Recombinant Human Synuclein, Alpha (non A4 component of amyloid precursor) E.coli N/A
    Human SNCA-7034H Recombinant Human SNCA, None tagged E.coli N/A
    Human SNCA-75H Recombinant Human SNCA, 112aa E.coli N/A
    Human SNCA-76H Recombinant Human SNCA, A30P Mutant E.coli N/A
    Human SNCA-77H Recombinant Human SNCA, A53T Mutant E.coli N/A
    Human SNCA-78H Recombinant Human Synuclein, Alpha (Non A4 Component of Amyloid Precursor) E.coli N/A
    Mouse SNCA-15673M Recombinant Mouse SNCA Protein Mammalian Cell His
    Mouse Snca-2730M Recombinant Mouse Synuclein, Alpha E.coli N/A
    Mouse Snca-386M Recombinant Mouse Snca Protein E.coli N/A
    Mouse Snca-5826M Recombinant Mouse Snca protein, His-tagged E.coli His
    Rat Snca-1372R Recombinant Rat Snca Protein, GST-tagged E.coli GST
    Rat Snca-387R Recombinant Rat Snca Protein E.coli N/A
    Rat SNCA-5638R Recombinant Rat SNCA Protein Mammalian Cell His
    Rat Snca-5827R Recombinant Rat Snca protein, His-tagged E.coli His
    Cynomolgus monkey SNCA-3389M Recombinant Cynomolgus monkey SNCA protein, His-SUMO-tagged E.coli His-SUMO
    Chicken SNCA-6239C Recombinant Chicken SNCA Mammalian Cell His
    Pongo abelii (Sumatran orangutan) SNCA-3390S Recombinant Sumatran orangutan SNCA, His-tagged E.Coli or Yeast His
    Ateles geoffroyi (Black-handed spider monkey) SNCA-3391A Recombinant Ateles geoffroyi (Black-handed spider monkey) SNCA, His-tagged E.Coli or Yeast His
    Monkey SNCA-3392L Recombinant Lagothrix lagotricha (Common woolly monkey) SNCA, His-tagged E.Coli or Yeast His
    Erythrocebus patas (Red guenon) (Cercopithecus patas) SNCA-3393E Recombinant Erythrocebus patas (Red guenon) (Cercopithecus patas) SNCA, His-tagged E.Coli or Yeast His
    Pan paniscus (Pygmy chimpanzee) (Bonobo) SNCA-3394P Recombinant Pan paniscus (Pygmy chimpanzee) (Bonobo) SNCA, His-tagged E.Coli or Yeast His
    Saguinus labiatus (Red-chested mustached tamarin) SNCA-3395S Recombinant Saguinus labiatus (Red-chested mustached tamarin) SNCA, His-tagged E.Coli or Yeast His

    SNCA involved in several pathways and played different roles in them. We selected most pathways SNCA participated on our site, such as Alzheimers disease, Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with SNCA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Alzheimers disease PLCB2; UQCR11; COX6A2; CALML5; NDUFB10; NDUFV2; GRIN2B; NDUFB1; NDUFA7; NDUFA12
    Parkinsons disease DRD1A; UBE2J1; UBE1Y1; NDUFA9; SDHA; COX7A1; NDUFB1; UCHL1; UBA7; NDUFB10

    SNCA has several biochemical functions, for example, alpha-tubulin binding, beta-tubulin binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SNCA itself. We selected most functions SNCA had, and list some proteins which have the same functions with SNCA. You can find most of the proteins on our site.

    Function Related Protein
    alpha-tubulin binding INO80; SERPINB1A; C9orf24; NDEL1; FAM110C; WASH1; DDL-2; B4GALT1; NCALD; ARL8B
    beta-tubulin binding RANBP10; SNCA; AKAP1; IFT74; OST4; EMD; FGF13; NDEL1; ADNP; ARL8A
    calcium ion binding SYT2; S100A3; CDH10; CALM; F2; THBS4A; KCNIP1; THBS1; DLL1; CGREF1
    copper ion binding S100V2; SNAI3; ANG; PAM; CUTC; MOXD1L; MT3; S100A5; IL1A; LOX
    cysteine-type endopeptidase inhibitor activity involved in apoptotic process GAS6; BIRC5; BIRC8; RPS6KA3; BIRC3; SERPINB1A; TNFSF14; IGF1RA; PRDX3; SNCA
    dynein binding NEFH; WDR81; DCTN6; WDR43; ATMIN; LRRC50; DCTN1; SERPINB1A; KATNA1; PAFAH1B1B
    NOT fatty acid binding SNCA; SERPINB1A
    ferrous iron binding SNCA; ALKBH3; BCO1; ALKBH1; SERPINB1A; HEPH; UROD; ACP5; ISCUB; ISCA1
    histone binding HIST3H3; NOC2L; HAT1; TBL1XR1; UIMC1; HIST1H4A; ELP2; TBL1X; HIST1H3I; NFKBIL2
    identical protein binding CRYAA; DHX8; HSPB8; MIEF1; DAPK2; PRC1; GBP1; GSTM3; NOL3; TRIM8
    kinesin binding AP1G1; KLC3; KIFAP3B; JIP1; KIF1B; ATCAY; AP1AR; KTN1; ARPC2; ACTB
    magnesium ion binding DOM3Z; FARS2; EPHX2; ENO3; ENOPH1; TREX2; PTENB; WEE2; ERN2; PPM1B
    microtubule binding MTUS2; KATNA1; KIF3C; WDR81; MAP1LC3C; GAS2L3; NPSNL; DPYSL2B; RGS14; GAPDH
    oxidoreductase activity DHRS13B; KDM1A; HSD17B12B; NOS2B; HEPHL1; CYP26C1; DCT; ALDH2.2; CYBASC3; TM9SF1
    NOT phospholipase D inhibitor activity SERPINB1A; SNCA
    phospholipase binding APOC2; PTPN11; SNCA; CALM2; WAS; Pla2r1; SERPINB1A; PDPK1; LMNB1; ARHGAP6
    phospholipid binding PICALMA; SYTL4; GOT2; NR5A1; APOEB; OTC; APOC3; FABP1; Defa4; PTAFR
    phosphoprotein binding PKD2; CSNK1D; CACNB2; RB1; MID2; MID1; SERPINB1A; DPYS; SFN; SNCA
    protein N-terminus binding SCFD1; KCNIP1; TRP53; SLC6A3; ACTN4; TBL1XR1; SNCA; ALOX5AP; TSC1; STX1A
    protein binding MGP; ARNTL2; KCTD9; TRAF2; GCET2; NFIX; RLTPR; VIP; CD1d1; LRRC3
    protein domain specific binding THRA; TJP1; PHRF1; RUNX2; YWHAE; HIST1H4B; PTPN11; BHLHE40; MLF1; ARFIP2
    tau protein binding BIN1; HDAC6; FKBP4; SNCA; S100B; PPP2R2A; APOE; SERPINB1A; DYRK1A; AATF
    transcription regulatory region DNA binding KDM1A; TAF7; XRCC5; TBL1X; NCOR1; CEBPA; SIX1; SREBF1; GATA5; ARID5A
    zinc ion binding TRIM35-31; KMT2E; LTN1; LHX1B; PIAS4B; AMZ2; FBXO30; APOBEC1; BIRC3; ARIH1L

    SNCA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SNCA here. Most of them are supplied by our site. Hope this information will be useful for your research of SNCA.

    Alvarez-Castelao, B; Gorostidi, A; et al. Epitope mapping of antibodies to alpha-synuclein in LRRK2 mutation carriers, idiopathic Parkinson disease patients, and healthy controls. FRONTIERS IN AGING NEUROSCIENCE 6:-(2014).
    Daher, JPL; Volpicelli-Daley, LA; et al. Abrogation of alpha-synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 111:9289-9294(2014).

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