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  • Official Full Name
  • v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
  • Background
  • This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
  • Synonyms
  • SRC; v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog; ASV; SRC1; c-SRC; p60-Src; proto-oncogene tyrosine-protein kinase Src; proto-oncogene c-Src; tyrosine kinase pp60c-src; tyrosine-protein kinase SRC-1; protooncogene SRC, Rous sarcoma; EC 2.7.10.2
Cat.#:SRC-2747HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human SRC Protein, MYC/DDK-tagged
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Cat.#:SRC-1100HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SRC protein, GST-tagged
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Cat.#:SRC-1358HTag:His|GST
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human SRC protein, His/GST-tagged
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Cat.#:SRC-192HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SRC, SH3 Domain, GST-tagged
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Cat.#:SRC-22HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SRC protein, His-tagged
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Cat.#:SRC-2947HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SRC, GST-tagged
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Cat.#:SRC-381HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human SRC
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Cat.#:SRC-533HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human SRC protein, His-tagged
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Cat.#:SRC-575HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SRC, GST-tagged
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Cat.#:SRC-79HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human SRC protein, Flag-tagged, Biotinylated
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Cat.#:Src-907MTag:His|GST
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Src, His & GST tagged
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Cat.#:SRC-4460RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SRC Protein, His-tagged
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Cat.#:SRC-7007CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SRC
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Cat.#:SRC-1128ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SRC
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Cat.#:Src-546RTag:GST
Source (Host):Sf 9 insect cellsSpecies:RSV
Product nameRecombinant RSV Src, GST-tagged
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Cat.#:SRC-191HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SRC, GST-tagged
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Cat.#:SRC-433HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human SRC, GST-tagged, Active
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Cat.#:Src-593MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Rous Sarcoma Oncogene, Domain
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Cat.#:Src-99MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Rous Sarcoma Oncogene, SH3 Domain
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Cat.#:SRC-29697THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameNative Human SRC
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Cat.#:SRC-487HCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human SRC cell lysate
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Cat.#:SRC-585MCLTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse SRC cell lysate
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Cat.#:Kit-0800Tag:N/A
Source (Host):Species:
Product namec-Src Kinase (Human) Assay/Inhibitor Screening Assay Kit
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Involved Pathway

SRC involved in several pathways and played different roles in them. We selected most pathways SRC participated on our site, such as ErbB signaling pathway, Rap signaling pathway, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SRC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
MAPK10; HRASA; PIK3R2; CAMK2G; MAPK1; NCK2B; BAD; CAMK2B; PAK2; RPS6KB1
Rap signaling pathway
PFN3; PLCG1; APBB1IP; VAV2; VEGFB; PGF; CALM2; HRAS; MAP2K2; TEK
Chemokine signaling pathway
PRKACA; RHOA; CX3CR1; Ccl9; CCL17; CCR9; CXCL8; AKT1; CCL4L2; CXCL12
Endocytosis
AP2M1A; BIN1; TGFB1; GRK1A; TFRC; H2-Q10; ASAP3; RAB11FIP3; HLA-G; KITA
VEGF signaling pathway
MAPK14A; PTK2AA; NOS3; HRAS; MAPK3; MAPK1; PTK2; RAC3A; PIK3R3; CDC42L
Focal adhesion
ITGA1; ITGA10; RAC3B; MAPK3; HRASB; IGF1R; ITGA4; XIAP; Reln; TNK2
Adherens junction
CSNK2B; SSX2IP; ACTB1; RHOA; EGFR; ACTN4; PTPRF; YES1; RAC1; CTNNA1
Tight junction
PARD6GB; HRASA; ACTN1; MYH1A; CLDN8; ACTB1; MYH1; CTTN; SHROOM1; PPP2R1B
Gap junction
GNAI2; GNAI3; HTR2B; TUBA4L; TUBA4A; PDGFC; MAP2K2A; GRB2A; PRKACAA; PRKACG
Platelet activation
PLCB4; PIK3R3; GNAQ; P2RY1; PRKCI; RHOA; ROCK2; ITGA2B; Adcy4; GUCY1B3
GABAergic synapse
GABBR1; GABARAP; GABRA3; GNG2; PLCL1; GABRB3; GABRR1; GABRB2; GNG12; GABRA2
Inflammatory mediator regulation of TRP channels
IL1B; PLCG1; PIK3CG; CYP4A10; PPP1CC; CALM3; PIK3CA; PLA2G6; HTR2A; PPP1CB
Regulation of actin cytoskeleton
PIP4K2C; PAK2; PIK3R1; ITGB8; PAK7; PDGFD; PIK3R3A; DIAPH3; SRC; RAC1A
GnRH signaling pathway
PLCB3; GRB2B; HRAS; PLD1; CALM3; EGFRA; GNA15.1; PLA2G4C; LHB; CGNRH-R
Estrogen signaling pathway
MMP9; GNAQ; KCNJ6; PIK3R3; PIK3CA; PIK3R5; HSPA1B; GNAS; CREB3L2; GABBR2
Prolactin signaling pathway
TNFRSF11A; IRF1; PIK3R3; PIK3CA; SHC1; MAPK3; INS2; SRC; AKT2; SOCS2
Thyroid hormone signaling pathway
MDM2; ACTB; TSC2; MED13; RXRB; PLCE1; PLCZ1; NOTCH1; PLCD1; KRAS
Oxytocin signaling pathway
CACNG4; GUCY1B3; MAP2K1; RYR1; PIK3R5; CAMK2B; FOS; PLA2G4D; PPP3R2; PPP1CB
Bacterial invasion of epithelial cells
CDC42; BCAR1; ELMO3; SEPT2; CTTN; SHC2; ACTB; PIK3R3; CAV2; PXN
Epithelial cell signaling in Helicobacter pylori infection
RAC1; ATP6V1G2; ADAM17; MET; CCL5; MAPK10; ATP6V1H; ATP6V0C; CXCR1; MAPK12
Shigellosis
NFKBIA; RIPK2; PFN4; IKBKG; ELMO3; ACTB; IKBKB; MAPK10; ITGB1; ROCK1
Tuberculosis
LAMP2; SYK; IL18; IL1B; NFYC; CALM1; RFXANK; AKT2; HLA-DRB3; ATP6V0C
Hepatitis B
IFNA1; HRAS; TGFB2; NFKB1; PCNA; GRB2; STAT6; NFKBIA; PIK3CG; MAPK1
Viral carcinogenesis
HIST1H2BJ; RANBP1; MAPKAPK2; TRAF5; EIF2AK2; SP100; HDAC7A; GTF2A2; CCNA2; GTF2B
Proteoglycans in cancer
WNT4; ANK2; PPP1CC; MDM2; SMO; Fzd4; FAS; MRAS; PRKCB; CCND1
Bladder cancer
DAPK3; RASSF1; TP53; E2F3; MYC; KRAS; IL-8; CDKN2A; NRAS; DAPK2

Protein Function

SRC has several biochemical functions, for example, ATP binding, SH2 domain binding, SH3/SH2 adaptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SRC itself. We selected most functions SRC had, and list some proteins which have the same functions with SRC. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PKLR; VWA8; HIPK3B; CHUK; PEX1; SARS2; CHKB; PANK1A; KIAA1804; PSMC1
Function SH2 domain binding
Related Protein PTK2; CTR9; LAX1; KHDRBS2; TRPV4; SKAP1; MS4A2; SYNGR3; SQSTM1; LILRB1
Function SH3/SH2 adaptor activity
Related Protein SHB; FCRL2; IRS4; TOB1; STAM; PTPN11; NCK1; SH3BGRL; LASP1; STAP1
Function enzyme binding
Related Protein NOS1; RPS2; CYB5A; TSPAN33; CSF3; HDHD2; RFC5; PEX5; C2orf56; KDM4C
Function ephrin receptor binding
Related Protein NTRK1; EFNB2; SRC; PTPN1; Anks1; EFNB1; EFNB2B; SIPA1L1; NTRK3; FYN
Function growth factor receptor binding
Related Protein FYN; SRC; SLC9A3R1; APP
Function heme binding
Related Protein HBE; CYB5B; CYGB1; CYP27C1; CYP4B1; HRG; HBA-X; CYP2AA8; CYP4F2; CYP39A1
Function hormone receptor binding
Related Protein JAK3; JAK2A; TNK2; SRC; TNK2B; JAK2B; TNK1
Function integrin binding
Related Protein NIPAL1; NOV; ANGPTL3; NISCH; PTPN2; WISP1A; COL4A3; WISP3; ICAM4; SEMA7A
Function ion channel binding
Related Protein FKBP1A; PDE4B; KCNE1L; PACS1; PKD1; CIB1; PHPT1; S100A10; SCN3B; SRC
Function kinase activity
Related Protein FAM20B; MAPKAPK2A; CAMKK1A; BCKDK; STK35L; CDC7; SMG1; MAPK12B; PFKMB; TNK2B
Function kinase binding
Related Protein JAKMIP1; PER1; CDC6; DGKQ; JAKMIP2; FAS; PFKFB1; PRPSAP1; PRDX3; SLC2A1
Function non-membrane spanning protein tyrosine kinase activity
Related Protein WEE1; FGR; ZAP70; FYNB; ITK; TEC; CSK; JAK2A; PTK2B; PKDCC
Function phosphoprotein binding
Related Protein SAG; DPYS; DPYSL3; SERPINB1A; TBL2; MID2; IGF2R; CACNB2; SFN; SNCA
Function protein binding
Related Protein CLDN8; GFER; DLAT; KCNQ1; MRTO4; ROR2; PGLS; HOOK3; HAUS1; BRCA2
Function protein kinase activity
Related Protein RPS6KAL; RPS6KA3B; PAK2; RIPK1L; TSSK1; PAK1; STK38A; CDK12; MAPKAPK2A; PRKACAA
Function protein tyrosine kinase activity
Related Protein CLK2; ZAP70; FER; ALK; FGFR4; TNK2; PTK2AB; FGFR1; EK1; MAP3K9
Function receptor binding
Related Protein NPPA; HIST2H3C2; GDNF; MLYCD; FGF8A; Ar; EDN3; SLC27A2; SERPINE1; SSTR3
Function scaffold protein binding
Related Protein KRT18; CRIPT; SHANK3; KRT5; KCNH2; NOS3; PANX1; DSP; SCN5A; HOMER1

Interacting Protein

SRC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SRC here. Most of them are supplied by our site. Hope this information will be useful for your research of SRC.
PTPN1; PTK2

SRC Related Articles

Liu, Y; Zhang, LW; et al. DNA-PKcs Deficiency Inhibits Glioblastoma Cell-Derived Angiogenesis After Ionizing Radiation. JOURNAL OF CELLULAR PHYSIOLOGY 230:1094-1103(2015).
He, YX; Liu, J; et al. Src inhibitor reduces permeability without disturbing vascularization and prevents bone destruction in steroid-associated osteonecrotic lesions in rabbits. SCIENTIFIC REPORTS 5:-(2015).

SRC Related Gene Family

GPCRs TGF