Active Native Human A2M Protein, Fast Form
|Product Overview :
|Native human A2M protein (Fast Form) without tag was purified from human plasma.
Extinction Coefficient: 0.81
- Gene Information
- Related Products
|The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified.
|Shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
|Molecular Mass :
|≥ 95% by SDS-PAGE
|> 1 year
|≤ -20 centigrade.
|Storage Buffer :
|100 mM Na Phosphate, pH 7.2
|Gene Name :
|A2M alpha-2-macroglobulin [Homo sapiens (human)]
|Official Symbol :
|A2M; alpha-2-macroglobulin; A2MD; CPAMD5; FWP007; S863-7; alpha-2-macroglobulin; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; alpha-2-M
|Gene ID :
|mRNA Refseq :
|Protein Refseq :
|UniProt ID :
|◆ Recombinant Protein
|Recombinant Mouse A2m Protein, His-tagged
|Recombinant Human A2M Protein, His (Fc)-Avi-tagged
|Recombinant Rat A2M Protein, His (Fc)-Avi-tagged
|Recombinant Human A2M Protein (Ser24-Ala1474), N-His tagged, Biotinylated
|Recombinant Pig a2M, His-tagged
|◆ Native Protein
|Native Rat Alpha-2-Macroglobulin
|Native Mouse Alpha-2-Macroglobulin
|Recombinant Human A2M cell lysate
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
It play an important role in the immune system, binding and neutralizing viruses, bacteria, reducing inflammation, and participating in immune regulation.
Studies of the A2M protein in lung disease have shown that it may work by inhibiting inflammation and reducing lung tissue damage.
The expression of A2M protein in organs or tissues such as liver, kidney, and lymphoid tissue is high.
Proteins eventually clear harmful proteins by capturing and binding to harmful proteins and then entering the cell through internalization.
A2M proteins show potential therapeutic targets in cardiovascular diseases and may have effects on cardiovascular diseases by modulating inflammatory responses and blood clotting.
A2M proteins are studied in many neurological diseases, such as Parkinson's disease, stroke, etc., and may be involved in processes such as inflammation and oxidative stress.
Customer Reviews (3)Write a review
It can be seen that the production process of A2M pays great attention to purity and biological activity, which makes its products have extremely high application value.
Short half-life and high clearance of A2M make them more suitable for use in emergency medical situations and provide more treatment options for patients.
The production process of A2M achieves efficient use of energy, reduces energy consumption, reduces carbon emissions, and is very environmentally friendly.
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