Active Native Human A2M Protein, Fast Form

• Cat.No.: A2M-01H
• Product Overview: Native human A2M protein (Fast Form) without tag was purified from human plasma.
  Extinction Coefficient: 0.81

Specification

• Description: The protein encoded by this gene is a protease inhibitor and cytokine transporter. It uses a bait-and-trap mechanism to inhibit a broad spectrum of proteases, including trypsin, thrombin and collagenase. It can also inhibit inflammatory cytokines, and it thus disrupts inflammatory cascades. Mutations in this gene are a cause of alpha-2-macroglobulin deficiency. This gene is implicated in Alzheimer's disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. A related pseudogene, which is also located on the p arm of chromosome 12, has been identified.
• Source: Human Plasma
• Species: Human
• Form: Lyophilized
• Bio-activity: Shown to be non reactive for HBsAg, anti-HCV, anti-HBc, and negative for anti-HIV 1 & 2 by FDA approved tests.
• Molecular Mass: 725 kDa
• Purity: ≥ 95% by SDS-PAGE
• Stability: > 1 year
• Storage: ≤ -20 centigrade.
• Storage Buffer: 100 mM Na Phosphate, pH 7.2

Gene Information

• Gene Name: A2M alpha-2-macroglobulin [Homo sapiens (human)]
• Official Symbol: A2M
• Synonyms: A2M; alpha-2-macroglobulin; A2MD; CPAMD5; FWP007; S863-7; alpha-2-macroglobulin; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5; alpha-2-M
• Gene ID: 2
• mRNA Refseq: NM_000014
• Protein Refseq: NP_000005
• MIM: 103950
• UniProt ID: P01023