Recombinant Human Serum Amyloid A1, His-tagged


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Recombinant Human Serum Amyloid A1, His-tagged

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Cat. No. : SAA1-5110H
Product Overview : Recombinant SAA1protein was expressed in E. coli and purified by using conventionalchromatography techniques.
Description : Serum amyloidA1(SAA1) protein is made primarily in the liver and circulates in low levelsin the blood. This protein appears to play a role in the immune system.Levels of this protein increase in the blood and other tissues underconditions of inflammation. SAA1 may help repair damaged tissues, acts as anantibacterial agent, and signal the migration of germ-fighting cells to sitesof infection. Elevated levels of SAA over time predispose secondaryamyloidosis, extracellular accumulation of amyloid fibrils, derived from a circulatingprecursor, in various tissues and organs. The most common form of amyloidosisoccurs secondary to chronic inflammatory disease, particularly rheumatoidarthritis.
Concentration : 1 mg/ml
Source : Human
Host : E.coli
Form : Suppliedas a liquid in 20mM Tris buffer, pH 8.0, containing 10% glycerol.
Purity : > 95% by SDS -PAGE
Molecular Mass : 13.9 kDa(125aa), confirmed by MALDI-TOF.
Applications : SDS-PAGE
Storage : Storeat 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg Cor - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.
OfficialSymbol : SAA1
Gene Name : SAA1serum amyloid A1 [ Homo sapiens ]
Synonyms : SAA1; serum amyloid A1; SAA; PIG4; SAA2; TP53I4; MGC111216; serumamyloid A protein; OTTHUMP00000232000; OTTHUMP00000232001;OTTHUMP00000236629; tumor protein p53 inducible protein 4
Gene ID : 6288
mRNA Refseq : NM_000331
Protein Refseq : NP_000322
MIM : 104750
UniProt ID : P02735
Chromosome Location : 11p15.1
Pathway : ActivatedTLR4 signalling; Advanced glycosylation endproduct receptor signaling;Amyloids; Class A/1 (Rhodopsin-like receptors); Folate Metabolism; Formylpeptide receptors bind formyl peptides and many other ligands; G alpha (i)signalling events; GPCR ligand binding; Immune System; Innate ImmunitySignaling; MyD88 dependent cascade initiated on endosome; RIG-I/MDA5 mediatedinduction of IFN-alpha/beta pathways; Selenium Pathway; Toll Like Receptor 10(TLR10) Cascade; Toll Receptor Cascades; Viral dsRNA:TLR3:TRIF ComplexActivates RIP1
Function : G-protein-coupledreceptor binding
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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