Native Bovine Pyruvate Dehydrogenase (lipoamide) Beta
Cat.No. : | PDHB-1860B |
Product Overview : | Native Bovine PDHBwas expessed in bovine heart. |
- Specification
- Gene Information
- Related Products
Cat. No. : | PDHB-1860B |
Description : | PDHB, also known aspyruvate dehydrogenase E1 component subunit beta, mitochondrial or PDHE1-B isan enzyme that in humans is encoded by the PDHB gene. The PDHB is anuclear-encoded mitochondrial multienzyme complex that catalyzes the overallconversion of pyruvate to acetyl-CoA and CO2, and provides the primary linkbetween glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex iscomposed of multiple copies of three enzymatic components: pyruvatedehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamidedehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and twobeta subunits. This gene encodes the E1 beta subunit. |
Form : | Liquid in 50 mMTris-HCl, pH 7.0 + 14 mM β-mercaptoethanol + 1 mM benzamidine +0.1 mM phenylmethanesulfonyl fluoride + 1 mM EDTA + 10% glycerol |
Source : | Bovine heart |
Purity : | > 90% asdetermined by SDS-PAGE analysis, subunit apparent Mr"s ~ 74,000 (E2), 53,000(E3), 41,000 (E1a), 48,000 (E3-BP) and 36,000 (E1b). Apparent Mr ~ 8,500,000by sedimentation equilibrium centrifugation. |
Concentration : | 0.2 mg/ml |
Specific Activity : | 12-18 µmol of NADHformed per minute per mg of protein with pyruvate as substrate. |
Storage : | Store in workingaliquots at -80°C. Avoid repeated freeze-thaw cycles. |
OfficialSymbol : | PDHB |
Gene Name : | PDHB pyruvate dehydrogenase(lipoamide) beta [ Bos taurus ] |
Synonyms : | PDHB; pyruvatedehydrogenase (lipoamide) beta; pyruvate dehydrogenase E1 component subunitbeta, mitochondrial; PDHE1-B; EC 1.2.4.1; PDHA; PDHAL; PDHCE1A; PHE1A; PHE1 |
Gene ID : | 613610 |
mRNA Refseq : | NM_001035435 |
Protein Refseq : | NP_001030512 |
UniProt ID : | P11966 |
Pathway : | Butanoatemetabolism; Citrate cycle (TCA cycle); Glycolysis/Gluconeogenesis; Metabolicpathways; Pyruvate metabolism; Pyruvate metabolism and Citric Acid (TCA)cycle; Pyruvate oxidation, pyruvate => acetyl-CoA; Regulation of pyruvatedehydrogenase (PDH) complex; The citric acid (TCA) cycle and respiratoryelectron transport; Valine, leucine and isoleucine biosynthesis; Valine,leucine and isoleucine biosynthesis; pyruvate dehydrogenase complex;superpathway of acetyl-CoA biosynthesis |
Function : | oxidoreductaseactivity; pyruvate dehydrogenase (acetyl-transferring) activity |
Products Types
◆ Recombinant Protein | ||
PDHB-3174R | Recombinant Rhesus Macaque PDHB Protein, His (Fc)-Avi-tagged | +Inquiry |
PDHB-6600M | Recombinant Mouse PDHB Protein, His (Fc)-Avi-tagged | +Inquiry |
PDHB-4003R | Recombinant Rat PDHB Protein, His (Fc)-Avi-tagged | +Inquiry |
PDHB-1497B | Recombinant Bacillus subtilis PDHB protein, His-tagged | +Inquiry |
PDHB-4343R | Recombinant Rat PDHB Protein | +Inquiry |
◆ Lysates | ||
PDHB-1322HCL | Recombinant Human PDHB cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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