Recombinant Human O-6-methylguanine-DNA Methyltransferase, T7-tagged

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Recombinant Human O-6-methylguanine-DNA Methyltransferase, T7-tagged

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Cat. No. : MGMT-814H
Product Overview : Recombinant MGMT protein, fused to T7-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques, 21646Da (207aa).
Description : Methylated-DNA-protein-cysteine methyltransferase is an enzyme that in humans is encoded by the MGMT gene.
Sequences of amino acids : MDKDCEMKRT TLDSPLGKLE LSGCEQGLHE IKLLGKGTSA ADAVEVPAPA AVLGGPEPLM QCTAWLNAYF HQPEAIEEEP VPALHHPVFQ QESFTRQVLW KLLKVVKFGE VISYQQLAAL AGNPKAARAV GGAMRGNPVP ILIPCHRVVC SSGAVGNYSG GLAVKEWLLA HEGHRLGKPG LGGSSGLAGA WLKGAGATSG SPPAGRN
Formulation : 10 mM Tris. pH 8.0. 0.1% Triton X-100. 0.002% NaN3
Purity : > 95% by SDS - PAGE
Applications : MS. SDS
PDBrendering based on 1eh6. Available structures:1eh6, 1eh7, 1eh8, 1qnt, 1t38, 1t39, 1yfh :

Gene Name : MGMT O-6-methylguanine-DNA methyltransferase [Homo sapiens]
Synonyms : MGMT; O-6-methylguanine-DNA methyltransferase; methylated-DNA-protein-cysteine methyltransferase; 6-O-methylguanine-DNA methyltransferase; methylguanine-DNA methyltransferase; O-6-methylguanine-DNA-alkyltransferase; EC2.1.1.63; O6-methylguanine-DNA methyltransferase
Gene ID : 4255
mRNA Refseq : NM_002412
Protein Refseq : NP_002403
MIM : 156569
UniProt ID : P16455
Chromosome Location : 10q26
Pathway : Reactome Event: DNA Repair
Function : DNA binding; DNA-methyltransferase activity; metal ion binding; methylated-DNA-[protein]-cystein S-methyltransferase activity; methyltransferase activity; transferase activity
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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