Native Human Coagulation Factor II

• Cat.No.: F2-1882H
• Product Overview: Native human F2 was expressedin Human plasma.

Specification

• Description: F2 is aserine protease protein that in humans is encoded by the F2 gene. Prothrombin(coagulation factor II) is proteolytically cleaved to form thrombin in thefirst step of the coagulation cascade, which ultimately results in thestemming of blood loss. F2 in turn acts as a serine protease that convertssoluble fibrinogen into insoluble strands of fibrin, as well as catalyzingmany other coagulation-related reactions.
• Source: Human Plasma
• Species: Human
• Form: Liquid in 0.1 MNaH2P04, pH 6.5.
• Molecular Mass: 35.4 kDa
• Storage: Store in workingaliquots at -20°C . Avoid repeated freeze-thaw cycles.
• Concentration: 5.0 mg/ml

Gene Information

• Gene Name: F2 coagulation factor II (thrombin) [ Homo sapiens ]
• Official Symbol: F2
• Synonyms: F2; coagulation factor II (thrombin); prothrombin; serine protease; prothrombin B-chain; PT; THPH1
• Gene ID: 2147
• mRNA Refseq: NM_000506
• Protein Refseq: NP_000497
• MIM: 176930
• UniProt ID: P00734
• Chromosome Location: 11p11-q12
• Pathway: Angiopoietin receptor Tie2-mediated signaling, organism-specific biosystem; Blood Clotting Cascade, organism-specific biosystem; Cell surface interactions at the vascular wall, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Common Pathway, organism-specific biosystem; Complement and Coagulation Cascades, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem
• Function: calcium ion binding; growth factor activity; peptidase activity; protein binding; receptor binding; contributes_to receptor binding; serine-type endopeptidase activity; thrombospondin receptor activity