Native Mouse Alpha-2-Macroglobulin


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Native Mouse Alpha-2-Macroglobulin

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Cat. No. : A2m-367M
Product Overview : Native Mouse A2m isprepared from Mouse Serum.
Description : A2mis a serum protease inhibitor that consists of two major polypeptides withmolecular weights of approximately 163 kDa and 35 kDa together with a minorpolypeptide of 185 kDa. A2m is able to inactivate an enormous variety ofproteinases (including serine-, cysteine-, aspartic-, andmetalloproteinases). A2m uses a bait region to bind proteinases. Theproteinase- A2m complex is recognized by macrophage receptors and clearedfrom the system. A2m function as an inhibitor of coagulation by inhibitingthrombin. A2m also functions as an inhibitor of fibrinolysis by inhibitingplasmin and kallikrein.
Form : 150 mM NaCl+10 mMSodium Phosphate pH 7.2
Source : Mouse Serum
Purity : > 90% by SDS-PAGE
Concentration : Typically>0.5mg/mL
Storage : Store ≤ -20°C.
Pathways : Complement and Coagulation Cascades
Crystal structure of alpha-2-macroglobulin. Rendered from PDB2P9R. :

Gene Name : A2m alpha-2-macroglobulin [ Musmusculus ]
Official Symbol : A2m
Synonyms : A2m;alpha-2-macroglobulin; A2mp; alpha-2-macroglobulin-P
Gene ID : 232345
mRNA Refseq : NM_175628
Protein Refseq : NP_783327
Chromosome Location : 6
Function : endopeptidaseinhibitor activity; enzyme binding; growth factor binding; interleukin-1binding; peptidase inhibitor activity; serine-type endopeptidase inhibitoractivity; tumor necrosis factor binding

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