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Active Recombinant Mouse Interleukin 23 Receptor, Fc-tagged

Cat.No. : Il23r-5657M
Product Overview : RecombinantMouse Il23r protein was expressed in Murine myeloma celllinewith the Fc part of Human IgG1 Pro100-Lys330 (C-terminus) and MouseIl23r Gly24-Asp372 (N-terminus).
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Cat. No. : Il23r-5657M
Description : Il23r isa heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunitthat is unique to IL-23, and a p40 subunit that is shared with IL-12. Thefunctional Il23r complex consists of two receptor subunits, the IL-12receptor beta 1 subunit (IL-12 Rβ1) and the IL-23-specific receptor subunit(IL-23 R). Mouse Il23r cDNA encodes a 644 amino acid (aa) type I transmembraneprotein with a 23 aa residue signal peptide, a 349 aa residue extracellulardomain, a 23 aa residue transmembrane domain and a 249 aa residue cytoplasmicregion.
Source : Mammalian cells
Form : Lyophilizedfrom a 0.2 μm filtered solution in PBS.
N-terminalSequence : Gly24
MolecularWeight : 66.8 kDa (monomer)
Activity : Measuredby its binding ability in a functional ELISA. Immobilized rm Il23r/FcChimera at 5 μg/mL (100 μL/well) can bind rmIL-23 with a linear range of 0.6-40ng/mL.
Endotoxin Level : <1.0EU per 1μg of the protein by the LAL method.
SDS-PAGE : 105 kDa,reducing conditions.
Purity : >90%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution : 100 μg/mLin sterile PBS
Storage : Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to-70°C under sterile conditions after reconstitution.
Gene Name : Il23r interleukin 23 receptor[ Mus musculus ]
Official Symbol : Il23r
Synonyms : Il23r; interleukin23 receptor; IL-23R; interleukin-23receptor; IL-23 receptor
Gene ID : 209590
mRNA Refseq : NM_144548
Protein Refseq : NP_653131
UniProt ID : Q8K4B4
Chromosome Location : 6
Pathway : Cytokine-cytokinereceptor interaction; Jak-STAT signaling pathway
Function : interleukin-23binding; interleukin-23 receptor activity; receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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How does IL23R activation affect T-cell differentiation? 12/22/2022

IL23R activation promotes Th17 cell differentiation.

Does IL23R have alternative splicing variants? 02/20/2022

IL23R has multiple alternative splicing variants.

Does IL23R have any post-translational modifications that affect its stability? 08/23/2021

IL23R undergoes phosphorylation that affects its stability.

What is the half-life of IL23R protein in activated T-cells? 08/21/2020

The half-life of IL23R protein in activated T-cells is approximately 48 hours.

Are there any microRNAs that regulate IL23R expression? 06/16/2020

MicroRNAs like miR-20a regulate IL23R expression.

How does IL23R contribute to cytokine release? 02/15/2019

IL23R contributes to the release of pro-inflammatory cytokines like IL-17.

What role does IL23R play in autoimmune diseases? 08/22/2018

IL23R is implicated in autoimmune diseases like Crohn's.

How does IL23R expression change during infection? 10/12/2017

IL23R expression is upregulated during bacterial infection.

Does IL23R form homodimers or heterodimers? 08/15/2016

IL23R forms heterodimers with IL-12Rβ1.

What intracellular pathways are activated by IL23R? 08/06/2016

IL23R activates the JAK-STAT and NF-κB pathways.

Customer Reviews (3)

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Reviews
10/21/2020

    High specificity in ELISA.

    04/28/2016

      Effective in autoimmune models.

      03/30/2016

        Suitable for receptor binding studies.

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