Active Recombinant Mouse Interleukin 23 Receptor, Fc-tagged
Cat.No. : | Il23r-5657M |
Product Overview : | RecombinantMouse Il23r protein was expressed in Murine myeloma celllinewith the Fc part of Human IgG1 Pro100-Lys330 (C-terminus) and MouseIl23r Gly24-Asp372 (N-terminus). |
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Cat. No. : | Il23r-5657M |
Description : | Il23r isa heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunitthat is unique to IL-23, and a p40 subunit that is shared with IL-12. Thefunctional Il23r complex consists of two receptor subunits, the IL-12receptor beta 1 subunit (IL-12 Rβ1) and the IL-23-specific receptor subunit(IL-23 R). Mouse Il23r cDNA encodes a 644 amino acid (aa) type I transmembraneprotein with a 23 aa residue signal peptide, a 349 aa residue extracellulardomain, a 23 aa residue transmembrane domain and a 249 aa residue cytoplasmicregion. |
Source : | Mammalian cells |
Form : | Lyophilizedfrom a 0.2 μm filtered solution in PBS. |
N-terminalSequence : | Gly24 |
MolecularWeight : | 66.8 kDa (monomer) |
Activity : | Measuredby its binding ability in a functional ELISA. Immobilized rm Il23r/FcChimera at 5 μg/mL (100 μL/well) can bind rmIL-23 with a linear range of 0.6-40ng/mL. |
Endotoxin Level : | <1.0EU per 1μg of the protein by the LAL method. |
SDS-PAGE : | 105 kDa,reducing conditions. |
Purity : | >90%,by SDS-PAGE under reducing conditions and visualized by silver stain. |
Reconstitution : | 100 μg/mLin sterile PBS |
Storage : | Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to-70°C under sterile conditions after reconstitution. |
Gene Name : | Il23r interleukin 23 receptor[ Mus musculus ] |
Official Symbol : | Il23r |
Synonyms : | Il23r; interleukin23 receptor; IL-23R; interleukin-23receptor; IL-23 receptor |
Gene ID : | 209590 |
mRNA Refseq : | NM_144548 |
Protein Refseq : | NP_653131 |
UniProt ID : | Q8K4B4 |
Chromosome Location : | 6 |
Pathway : | Cytokine-cytokinereceptor interaction; Jak-STAT signaling pathway |
Function : | interleukin-23binding; interleukin-23 receptor activity; receptor activity |
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◆ Lysates | ||
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionIL23R activation promotes Th17 cell differentiation.
IL23R has multiple alternative splicing variants.
IL23R undergoes phosphorylation that affects its stability.
The half-life of IL23R protein in activated T-cells is approximately 48 hours.
MicroRNAs like miR-20a regulate IL23R expression.
IL23R contributes to the release of pro-inflammatory cytokines like IL-17.
IL23R is implicated in autoimmune diseases like Crohn's.
IL23R expression is upregulated during bacterial infection.
IL23R forms heterodimers with IL-12Rβ1.
IL23R activates the JAK-STAT and NF-κB pathways.
Customer Reviews (3)
Write a reviewHigh specificity in ELISA.
Effective in autoimmune models.
Suitable for receptor binding studies.
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