Recombinant Bovine Enterokinase
Cat.No. : | PRSS7-02B |
Product Overview : | Recombinant Bovine Enterokinase produced in Pichia. Pastoris is a single glycosylated polypeptide chain containing 235 amino acids and having a molecular mass of approximately 43.0 kDa. |
- Specification
- Gene Information
- Related Products
Cat. No. : | PRSS7-02B |
Description : | Enterokinase is a serine proteinase in the duodenum that plays a critical role in mammalian digestion. It is the physiological activator of pancreatic trypsinogen. It converts trypsinogen into its active form trypsin, by cleaving its aminoterminal hexapeptide Val(Asp)4-Lys. More recently, the enterokinase has been shown to have a broad utility in cleaving fusion proteins produced in Escherichia coli. The enzyme is particularly suitable for this role because of its high degree of specificity, its tolerance to a wide range of reaction conditions, and the fact that its recognition sequence lies entirely on the aminoterminal side of the scissile bond. This enzymatic activity allows release of carboxyl-terminal fusion partners from fusion proteins without leaving unwanted amino acid residues on their amino termini. |
Unit Definition : | One unit is defined as the amount of enzyme needed to cleave 50 ug of fusion protein in 16 hours to 95% completion at 25°C in a buffer containing 25 mM Tris-HCl, pH 7.6, 50 mM NaCl, and 2 mM CaCl2. |
Formulation : | 50 mM Tris-HCl, pH 8.0, 0.5M NaCl and 50% glycerol. |
Physical Appearance : | Sterile liquid |
Endotoxin : | Less than 1EU/mg of rbEK as determined by LAL method. |
Storage : | One year when stored at -20°C. Avoid repeated freeze/thaw cycles. |
Enzyme Commission Number : | EC3.4.21.9 |
Reaction : | The reactioncatalysedby Enteropeptidase: trypsinogen → trypsin + octapeptide Enteropeptidase cleaves after Lysine if the Lys is preceded by four Asp and not followed by a Pro. |
Gene Name : | protease, serine, 7 (enterokinase) |
Synonyms : | PRSS7; EC 3.4.21.9; ENTK; Enterokinase; MGC133046; enterokinase; enteropeptidase; proenterokinase; Enteropeptidase precursor; Serine protease 7; human enterokinase; EC 3.4.21.9; protease, serine, 7; serine protease (enterokinase); protease, serine, 7 (enterokinase) |
Gene ID : | 282009 |
mRNA Refseq : | NM_174439 |
Protein Refseq : | NP_776864 |
UniProt ID : | P98072 |
Chromosome Location : | 1 |
Function : | peptidase activity;scavenger receptor activity |
Products Types
◆ Recombinant Protein | ||
PRSS7-25B | Recombinant Bovine Enterokinase | +Inquiry |
PRSS7-286B | Recombinant Bovine PRSS7 | +Inquiry |
◆ Native Protein | ||
PRSS7-42P | Native Porcine Enterokinase | +Inquiry |
◆ Assay kits | ||
Kit-0739 | PRSS7 Assay/Inhibitor Screening Fluorometric Kit | +Inquiry |
Kit-0738 | PRSS7 Activity Fluorometric Assay Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionPRSS7 dysregulation has been linked to conditions such as pancreatitis and pancreatic cancer, highlighting its clinical significance in these diseases.
PRSS7 has been studied in the context of inflammatory conditions and may have implications beyond pancreatic disorders.
The potential side effects of targeting PRSS7 for therapy would need careful consideration and further research.
Some diagnostic tests measure PRSS7 levels in blood or other biological samples to assess pancreatic function and health.
Yes, abnormal levels or activity of PRSS7 have been implicated in certain pancreatic disorders, making it a potential biomarker for diagnostic purposes.
Customer Reviews (3)
Write a reviewTheir expertise and prompt assistance can effectively address any concerns or challenges that may arise during the experimental process.
The PRSS7 protein is of exceptional quality, making it an ideal choice to meet my experimental requirements.
In addition to its outstanding quality, the manufacturer of the PRSS7 protein provides excellent technical support, which is a valuable asset for researchers
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