Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

Recombinant Bovine Enterokinase

Cat.No. : PRSS7-02B
Product Overview : Recombinant Bovine Enterokinase produced in Pichia. Pastoris is a single glycosylated polypeptide chain containing 235 amino acids and having a molecular mass of approximately 43.0 kDa.
  • Specification
  • Gene Information
  • Related Products
Cat. No. : PRSS7-02B
Description : Enterokinase is a serine proteinase in the duodenum that plays a critical role in mammalian digestion. It is the physiological activator of pancreatic trypsinogen. It converts trypsinogen into its active form trypsin, by cleaving its aminoterminal hexapeptide Val(Asp)4-Lys. More recently, the enterokinase has been shown to have a broad utility in cleaving fusion proteins produced in Escherichia coli. The enzyme is particularly suitable for this role because of its high degree of specificity, its tolerance to a wide range of reaction conditions, and the fact that its recognition sequence lies entirely on the aminoterminal side of the scissile bond. This enzymatic activity allows release of carboxyl-terminal fusion partners from fusion proteins without leaving unwanted amino acid residues on their amino termini.
Unit Definition : One unit is defined as the amount of enzyme needed to cleave 50 ug of fusion protein in 16 hours to 95% completion at 25°C in a buffer containing 25 mM Tris-HCl, pH 7.6, 50 mM NaCl, and 2 mM CaCl2.
Formulation : 50 mM Tris-HCl, pH 8.0, 0.5M NaCl and 50% glycerol.
Physical Appearance : Sterile liquid
Endotoxin : Less than 1EU/mg of rbEK as determined by LAL method.
Storage : One year when stored at -20°C. Avoid repeated freeze/thaw cycles.
Enzyme Commission Number : EC3.4.21.9
Reaction : The reactioncatalysedby Enteropeptidase: trypsinogen → trypsin + octapeptide Enteropeptidase cleaves after Lysine if the Lys is preceded by four Asp and not followed by a Pro.
Gene Name : protease, serine, 7 (enterokinase)
Synonyms : PRSS7; EC 3.4.21.9; ENTK; Enterokinase; MGC133046; enterokinase; enteropeptidase; proenterokinase; Enteropeptidase precursor; Serine protease 7; human enterokinase; EC 3.4.21.9; protease, serine, 7; serine protease (enterokinase); protease, serine, 7 (enterokinase)
Gene ID : 282009
mRNA Refseq : NM_174439
Protein Refseq : NP_776864
UniProt ID : P98072
Chromosome Location : 1
Function : peptidase activity;scavenger receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (5)

Ask a question
How is PRSS7 involved in pancreatic diseases? 04/07/2023

PRSS7 dysregulation has been linked to conditions such as pancreatitis and pancreatic cancer, highlighting its clinical significance in these diseases.

In what other diseases or conditions might PRSS7 play a role? 07/30/2022

PRSS7 has been studied in the context of inflammatory conditions and may have implications beyond pancreatic disorders.

Are there any side effects associated with manipulating PRSS7 levels for therapeutic purposes? 03/18/2020

The potential side effects of targeting PRSS7 for therapy would need careful consideration and further research.

Are there any diagnostic tests specifically targeting PRSS7 levels? 02/22/2019

Some diagnostic tests measure PRSS7 levels in blood or other biological samples to assess pancreatic function and health.

Are there any clinical applications of PRSS7 in disease diagnosis? 12/03/2018

Yes, abnormal levels or activity of PRSS7 have been implicated in certain pancreatic disorders, making it a potential biomarker for diagnostic purposes.

Customer Reviews (3)

Write a review
Reviews
02/18/2023

    Their expertise and prompt assistance can effectively address any concerns or challenges that may arise during the experimental process.

    06/05/2020

      The PRSS7 protein is of exceptional quality, making it an ideal choice to meet my experimental requirements.

      06/11/2018

        In addition to its outstanding quality, the manufacturer of the PRSS7 protein provides excellent technical support, which is a valuable asset for researchers

        Ask a Question for All PRSS7 Products

        Required fields are marked with *

        My Review for All PRSS7 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends