"PRTN3" Related Products

Native Human Proteinase 3

Cat.No. : PRTN3-242H
Product Overview : Purified Native Human Azurophil Granules Proteinase 3
Description : Recent studies show a potential role for the serine protease PR3 in determining mortality and incidence of heart failure following AMI.PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. In human neutrophils proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. PR3 is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, as the major autoantigen of c-ANCA and is strongly expressed in lung tissue of patients with Wegener"s granulomatosis.
Source : Human Azurophil Granules
Species : Human
Form : Liquid
Molecular Mass : 29000
Purity : >96% by SDS-PAGE
Storage : Below -20 °C, Avoid repeat freeze-thaws.
Gene Name : PRTN3 proteinase 3 [ Homo sapiens ]
Official Symbol : PRTN3
Synonyms : PRTN3; proteinase 3; myeloblastin; ACPA; AGP7; C ANCA; MBT; P29; PR 3; serine proteinase; neutrophil; Wegener granulomatosis autoantigen; NP-4; C-ANCA antigen; wegener autoantigen; leukocyte proteinase 3; neutrophil proteinase 4; azurophil granule protein
Gene ID : 5657
mRNA Refseq : NM_002777
Protein Refseq : NP_002768
MIM : 177020
UniProt ID : P24158
Chromosome Location : 19p13.3
Pathway : C-MYB transcription factor network, organism-specific biosystem;
Function : enzyme binding; peptidase activity; protein binding; serine-type endopeptidase activity; serine-type peptidase activity;

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