Native Human Proteinase 3

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Native Human Proteinase 3

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Cat.No. : PRTN3-243H
Product Overview : Purified Native Human Neutrophils Proteinase 3. CAS Number: 128028-50-2; E.C. Number: 3.4.21.76
Description : Current Research suggests that PR3 may represent a clinically useful marker of prognosis after an AMI as part of a multimarker strategy. It is the major target antigen of antineutrophil cytoplasmic autoantibodies (ANCA) in Wegener"s granulomatosis and is contained in the azurophilic granules of polymorphonuclear neutrophils, the dominant cell type in vascular lesions during the early stages of systemic vasculitis.
Source : Human Neutrophils
Species : Human
Form : Solution in 0.05 M sodium acetate, 0.7 M sodium chloride; pH: 6.0
Bio-activity : Typically >0.1 U/mg protein
Purity : >96% by SDS-PAGE, Identity confirmed by Western Blot
Unit Definition : One unit will hydrolize one micromole of Methoxy succinyl-alanine-alanine-proline-valine-p-nitroanilide per minute at 37C and pH 7.5
Storage : Below -20 °C Long-Term.
Concentration : Typically >0.5 mg protein/mL
Gene Name : PRTN3 proteinase 3 [ Homo sapiens ]
Official Symbol : PRTN3
Synonyms : PRTN3; proteinase 3; myeloblastin; ACPA; AGP7; C ANCA; MBT; P29; PR 3; serine proteinase; neutrophil; Wegener granulomatosis autoantigen; NP-4; C-ANCA antigen; wegener autoantigen; leukocyte proteinase 3; neutrophil proteinase 4; azurophil granule protein
Gene ID : 5657
mRNA Refseq : NM_002777
Protein Refseq : NP_002768
MIM : 177020
UniProt ID : P24158
Chromosome Location : 19p13.3
Pathway : C-MYB transcription factor network, organism-specific biosystem;
Function : enzyme binding; peptidase activity; protein binding; serine-type endopeptidase activity; serine-type peptidase activity;

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