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Recombinant Human NF1, GST-tagged

Cat.No. : NF1-335H
Product Overview : Recombinant Human NF1(2719 a.a. - 2818 a.a.), fused with GST-tag at N-terminal, was expressed in wheat germ.
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Description : This gene product appears to function as a negative regulator of the ras signal transduction pathway. Mutations in this gene have been linked to neurofibromatosis type 1, juvenile myelomonocytic leukemia and Watson syndrome. The mRNA for this gene is subject to RNA editing (CGA>UGA->Arg1306Term) resulting in premature translation termination. Alternatively spliced transcript variants encoding different isoforms have also been described for this gene.
Source : Wheat germ
Species : Human
Tag : GST
Molecular Mass : 36.74 kDa
AA Sequence : DTYLPGIDEETSEESLLTPTSPYPP ALQSQLSITANLNLSNSMTSLATSQ HSPGIDKENVELSPTTGHCNSGRTR HGSASQVQKQRSAGSFKRNSIKKIV
Applications : ELISA; WB-Re; AP; Array
Storage : Store at -80°C. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : NF1 neurofibromin 1 [ Homo sapiens (human) ]
Official Symbol : NF1
Synonyms : NF1; WSS; NFNS; VRNF; neurofibromin 1; neurofibromin; neurofibromatosis-related protein NF-1
Gene ID : 4763
mRNA Refseq : NM_000267
Protein Refseq : NP_000258
MIM : 613113
UniProt ID : P21359
Chromosome Location : 17q11.2
Pathway : ATF-2 transcription factor network; FOXA2 and FOXA3 transcription factor networks; Integrated Breast Cancer Pathway
Function : Ras GTPase activator activity; phosphatidylcholine binding; phosphatidylethanolamine binding

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What is the primary function of the NF1 gene and its encoded protein? 11/05/2022

The NF1 gene encodes neurofibromin, a protein primarily known for its role as a tumor suppressor. It regulates cell growth and differentiation.

How do mutations in the NF1 gene contribute to tumorigenesis? 11/21/2021

Mutations in the NF1 gene can lead to a loss of neurofibromin function, resulting in uncontrolled RAS activation and increased cell proliferation, contributing to tumorigenesis.

How is the NF1 protein involved in the RAS/MAPK signaling pathway? 02/19/2021

Neurofibromin, the product of the NF1 gene, acts as a GTPase-activating protein (GAP) for RAS, accelerating the conversion of active RAS-GTP to its inactive form RAS-GDP, thereby negatively regulating the RAS/MAPK pathway.

Are there any known interactions between NF1 and other tumor suppressor genes or oncogenes? 06/16/2020

NF1 interacts with several proteins in cellular pathways, including c-Raf, mTOR, and adenylate cyclase. Its dysregulation can influence the activity of these proteins and associated pathways.

How does NF1 influence cell growth and differentiation? 11/26/2019

By regulating the RAS/MAPK pathway, NF1 plays a crucial role in controlling cell growth, differentiation, and apoptosis.

What are the current therapeutic strategies targeting NF1-related disorders? 02/17/2019

Current therapeutic strategies for NF1-related disorders include surgical removal of tumors, targeted therapies like MEK inhibitors for plexiform neurofibromas, and regular monitoring for associated complications.

What are the clinical manifestations of Neurofibromatosis Type 1, the disorder associated with NF1 mutations? 02/13/2019

Neurofibromatosis Type 1 is characterized by multiple café-au-lait spots, skinfold freckling, neurofibromas, optic pathway gliomas, and certain bone abnormalities, among other manifestations.

Customer Reviews (3)

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Reviews
07/08/2021

    Clear instructions, easy protocol.

    03/15/2021

      Packaging was secure, intact.

      06/27/2020

        Product arrived in good condition.

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