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Recombinant Rat Interleukin 25

Cat. No.: Il25-90R
Product Overview: Recombinant Rat Interleukin-17E produced inE.Coliis a homodimeric, non-glycosylated polypeptide chain containing 145 amino acids and having a molecular mass of 35.5 kDa. The Rat IL-25 is purified by proprietary chromatographic techniques.
Description: IL-25 also called IL-17E cytokine has a sequence similarity with IL17. IL-17E indluces NF-kappaB activation, and stimulates the production of IL-8. IL17E and IL17B are ligands for the cytokine receptor IL17BR. IL-25 is a proinflammatory cytokine favoring Th2-type immune response. The upregulation of costimulation-induced IL-17E receptors and release of cytokines and chemokines from IL-17E treated costimulated Th cells are differentially regulated by intracellular JNK, p38 MAPK and NF-kappaB activity. Blocking Iinterleukin-25 prevents airway hyperresponsiveness, a critical feature of clinical asthma. IL25 produced by innate effector eosinophils and basophils increase the allergic inflammation by enhancing the maintenance and functions of TSLP-DC activated adaptive Th2 memory cells. Over expression of IL-25 up-regulates gene expression of Th2 cytokines and induces growth retardation, jaundice, and multiorgan inflammation in a transgenic mouse model. IL-25 contributes to the induction and maintenance of eosinophilic inflammation by acting on lung fibroblasts which supports the fact that IL-17E is an important factor in asthma pathophysiology. IL-17E operates by amplifying TH2 cell-mediated allergic airway inflammation but doesn't induce allergic inflammation in vivo.
Source: Escherichia Coli.
Amino Acid Sequence: CSHLPRCCPS KQQEFPEEWL KWNPAPVSPP EPLRHTHHPE SCRASKDGPL NSRAISPWSY ELDRDLNRVP QDLYHARCLC PHCVSLQTGS HMDPMGNSVP LYHNQTVFYR RPCHGEQGAH GRYCLERRLY RVSLACVCVR PRMMA
Physical Appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
Purity: Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Formulation: Lyophilized from a concentrated (1mg/ml) solution containing no additives.
Solubility: It is recommended to reconstitute the lyophilized Interleukin Rat IL25 in sterile 10 mM HCL not less than 100 µg/ml, which can then be further diluted to other aqueous solutions.
Specific Activity: Rat IL-17A is fully biologically active when compared to standards via dose-dependent induction of IL-6 production in cultured rat fibroblasts.
Stability: Lyophilized Interleukin Rat IL17E although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Rat IL-25 should be stored at 4°Cbetween 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Gene Name: Il25 interleukin 25 [ Rattus norvegicus ]
Synonyms: Il25; interleukin 25; RGD1561632;rgd1561632_predicted; similar to IL25; similar to il25 (predicted); similar to IL25 (predicted); RGD1561632_predicted; LOC501996
Gene ID: 501996
mRNA Refseq: XM_577423
Protein Refseq: XP_577423
Chromosome Location: 15p13
Pathway: Cytokine-cytokine receptor interaction
Function: cytokine activity

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